Role of Tyk-2 in Th9 and Th17 cells in allergic asthma

In a murine model of allergic asthma, we found that Tyk-2((−/−)) asthmatic mice have induced peribronchial collagen deposition, mucosal type mast cells in the lung, IRF4 and hyperproliferative lung Th2 CD4(+) effector T cells over-expressing IL-3, IL-4, IL-5, IL-10 and IL-13. We also observed increa...

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Detalles Bibliográficos
Autores principales: Übel, Caroline, Graser, Anna, Koch, Sonja, Rieker, Ralf J., Lehr, Hans A., Müller, Mathias, Finotto, Susetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127519/
https://www.ncbi.nlm.nih.gov/pubmed/25109392
http://dx.doi.org/10.1038/srep05865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127519/
https://www.ncbi.nlm.nih.gov/pubmed/25109392
http://dx.doi.org/10.1038/srep05865

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