Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation

The NMDAR (N-methyl-D-aspartate receptor) is a central regulator of synaptic plasticity and learning and memory. hDAAO (human D-amino acid oxidase) indirectly reduces NMDAR activity by degrading the NMDAR co-agonist D-serine. Since NMDAR hypofunction is thought to be a foundational defect in schizop...

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Detalles Bibliográficos
Autores principales: Terry-Lorenzo, Ryan T., Chun, Lawrence E., Brown, Scott P., Heffernan, Michele L. R., Fang, Q. Kevin, Orsini, Michael A., Pollegioni, Loredano, Hardy, Larry W., Spear, Kerry L., Large, Thomas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127593/
https://www.ncbi.nlm.nih.gov/pubmed/25001371
http://dx.doi.org/10.1042/BSR20140071

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