Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages()

Recent advances suggest that there is a stochastic contribution to the proliferation and fate choice of retinal progenitors. How does this stochasticity fit with the progression of temporal competence and the transcriptional hierarchies that also influence cell division and cell fate in the developi...

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Detalles Bibliográficos
Autores principales: Boije, Henrik, MacDonald, Ryan B, Harris, William A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Current Biology 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127786/
https://www.ncbi.nlm.nih.gov/pubmed/24637222
http://dx.doi.org/10.1016/j.conb.2014.02.014
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author Boije, Henrik
MacDonald, Ryan B
Harris, William A
author_facet Boije, Henrik
MacDonald, Ryan B
Harris, William A
author_sort Boije, Henrik
collection PubMed
description Recent advances suggest that there is a stochastic contribution to the proliferation and fate choice of retinal progenitors. How does this stochasticity fit with the progression of temporal competence and the transcriptional hierarchies that also influence cell division and cell fate in the developing retina? Where may stochasticity arise in the system and how do we make progress in this field when we may never fully explain the behavior of individual progenitor cells?
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spelling pubmed-41277862014-08-14 Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages() Boije, Henrik MacDonald, Ryan B Harris, William A Curr Opin Neurobiol Article Recent advances suggest that there is a stochastic contribution to the proliferation and fate choice of retinal progenitors. How does this stochasticity fit with the progression of temporal competence and the transcriptional hierarchies that also influence cell division and cell fate in the developing retina? Where may stochasticity arise in the system and how do we make progress in this field when we may never fully explain the behavior of individual progenitor cells? Current Biology 2014-08 /pmc/articles/PMC4127786/ /pubmed/24637222 http://dx.doi.org/10.1016/j.conb.2014.02.014 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Boije, Henrik
MacDonald, Ryan B
Harris, William A
Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages()
title Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages()
title_full Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages()
title_fullStr Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages()
title_full_unstemmed Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages()
title_short Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages()
title_sort reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127786/
https://www.ncbi.nlm.nih.gov/pubmed/24637222
http://dx.doi.org/10.1016/j.conb.2014.02.014
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AT harriswilliama reconcilingcompetenceandtranscriptionalhierarchieswithstochasticityinretinallineages

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