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Cardiovascular Autonomic Neuropathy Contributes to Sleep Apnea in Young and Lean Type 1 Diabetes Mellitus Patients

Knowledge about association between sleep apnea and cardiovascular autonomic neuropathy (CAN) in type 1 diabetes mellitus (T1DM) might give some insight into the pathogenesis of this condition in these patients. In obese patients, excessive central adiposity, including a large neck circumference, ca...

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Autores principales: Janovsky, Carolina Castro Porto Silva, Rolim, Luiz Clemente de Souza Pereira, de Sá, João Roberto, Poyares, Dalva, Tufik, Sergio, Silva, Ademir Baptista, Dib, Sergio Atala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127968/
https://www.ncbi.nlm.nih.gov/pubmed/25157241
http://dx.doi.org/10.3389/fendo.2014.00119
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author Janovsky, Carolina Castro Porto Silva
Rolim, Luiz Clemente de Souza Pereira
de Sá, João Roberto
Poyares, Dalva
Tufik, Sergio
Silva, Ademir Baptista
Dib, Sergio Atala
author_facet Janovsky, Carolina Castro Porto Silva
Rolim, Luiz Clemente de Souza Pereira
de Sá, João Roberto
Poyares, Dalva
Tufik, Sergio
Silva, Ademir Baptista
Dib, Sergio Atala
author_sort Janovsky, Carolina Castro Porto Silva
collection PubMed
description Knowledge about association between sleep apnea and cardiovascular autonomic neuropathy (CAN) in type 1 diabetes mellitus (T1DM) might give some insight into the pathogenesis of this condition in these patients. In obese patients, excessive central adiposity, including a large neck circumference, can contribute to obstructive sleep apnea (OSA). Its presence in non-obese patients, however, indicates that it could be correlated with autonomic neuropathy. The aim of this study was to compare the prevalence of OSA in young and lean T1DM patients with and without CAN. We studied 20 adult, non-obese, T1DM patients who were divided into two groups according to the results of the cardiovascular autonomic reflex tests (CARTs). These two groups (9 with CAN and 11 without CAN) were compared to a control group of 22 healthy individuals, who were matched by age and BMI. A polysomnography was performed and sleep was analyzed. The CAN+ group had a significantly higher prevalence of sleep apnea compared to the other groups (67% CAN+; 23% CAN−; 4.5% controls: CAN+ vs. Control; p = 0.006 and CAN+ vs. CAN−; p = 0.02). The CAN− group had higher sleep efficiency compared to the CAN+ group, demonstrating impaired sleep architecture in diabetics with this chronic complication. In conclusion, OSA may be related to the presence of CAN in young and lean T1DM patients. It could contribute to worse the prognosis and reducing the quality of life of these patients without specific treatment of these conditions.
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spelling pubmed-41279682014-08-25 Cardiovascular Autonomic Neuropathy Contributes to Sleep Apnea in Young and Lean Type 1 Diabetes Mellitus Patients Janovsky, Carolina Castro Porto Silva Rolim, Luiz Clemente de Souza Pereira de Sá, João Roberto Poyares, Dalva Tufik, Sergio Silva, Ademir Baptista Dib, Sergio Atala Front Endocrinol (Lausanne) Endocrinology Knowledge about association between sleep apnea and cardiovascular autonomic neuropathy (CAN) in type 1 diabetes mellitus (T1DM) might give some insight into the pathogenesis of this condition in these patients. In obese patients, excessive central adiposity, including a large neck circumference, can contribute to obstructive sleep apnea (OSA). Its presence in non-obese patients, however, indicates that it could be correlated with autonomic neuropathy. The aim of this study was to compare the prevalence of OSA in young and lean T1DM patients with and without CAN. We studied 20 adult, non-obese, T1DM patients who were divided into two groups according to the results of the cardiovascular autonomic reflex tests (CARTs). These two groups (9 with CAN and 11 without CAN) were compared to a control group of 22 healthy individuals, who were matched by age and BMI. A polysomnography was performed and sleep was analyzed. The CAN+ group had a significantly higher prevalence of sleep apnea compared to the other groups (67% CAN+; 23% CAN−; 4.5% controls: CAN+ vs. Control; p = 0.006 and CAN+ vs. CAN−; p = 0.02). The CAN− group had higher sleep efficiency compared to the CAN+ group, demonstrating impaired sleep architecture in diabetics with this chronic complication. In conclusion, OSA may be related to the presence of CAN in young and lean T1DM patients. It could contribute to worse the prognosis and reducing the quality of life of these patients without specific treatment of these conditions. Frontiers Media S.A. 2014-08-11 /pmc/articles/PMC4127968/ /pubmed/25157241 http://dx.doi.org/10.3389/fendo.2014.00119 Text en Copyright © 2014 Janovsky, Rolim, Sá, Poyares, Tufik, Silva and Dib. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Janovsky, Carolina Castro Porto Silva
Rolim, Luiz Clemente de Souza Pereira
de Sá, João Roberto
Poyares, Dalva
Tufik, Sergio
Silva, Ademir Baptista
Dib, Sergio Atala
Cardiovascular Autonomic Neuropathy Contributes to Sleep Apnea in Young and Lean Type 1 Diabetes Mellitus Patients
title Cardiovascular Autonomic Neuropathy Contributes to Sleep Apnea in Young and Lean Type 1 Diabetes Mellitus Patients
title_full Cardiovascular Autonomic Neuropathy Contributes to Sleep Apnea in Young and Lean Type 1 Diabetes Mellitus Patients
title_fullStr Cardiovascular Autonomic Neuropathy Contributes to Sleep Apnea in Young and Lean Type 1 Diabetes Mellitus Patients
title_full_unstemmed Cardiovascular Autonomic Neuropathy Contributes to Sleep Apnea in Young and Lean Type 1 Diabetes Mellitus Patients
title_short Cardiovascular Autonomic Neuropathy Contributes to Sleep Apnea in Young and Lean Type 1 Diabetes Mellitus Patients
title_sort cardiovascular autonomic neuropathy contributes to sleep apnea in young and lean type 1 diabetes mellitus patients
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127968/
https://www.ncbi.nlm.nih.gov/pubmed/25157241
http://dx.doi.org/10.3389/fendo.2014.00119
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