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Investigating G protein signalling bias at the glucagon-like peptide-1 receptor in yeast

BACKGROUND AND PURPOSE: The glucagon-like peptide 1 (GLP-1) receptor performs an important role in glycaemic control, stimulating the release of insulin. It is an attractive target for treating type 2 diabetes. Recently, several reports of adverse side effects following prolonged use of GLP-1 recept...

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Detalles Bibliográficos
Autores principales: Weston, C, Poyner, D, Patel, V, Dowell, S, Ladds, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128063/
https://www.ncbi.nlm.nih.gov/pubmed/24712679
http://dx.doi.org/10.1111/bph.12716