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Modulation of imidazoline I(2) binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats

BACKGROUND AND PURPOSE: CR4056 is a novel imidazoline-2 (I(2)) ligand exhibiting potent analgesic activity in animal models of pain. In this study, we investigated the effects of CR4056 in a well-established model of postoperative pain where rats develop hyperalgesia in the injured hind paw. EXPERIM...

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Detalles Bibliográficos
Autores principales:	Lanza, Marco, Ferrari, Flora, Menghetti, Ilaria, Tremolada, Dario, Caselli, Gianfranco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128066/ https://www.ncbi.nlm.nih.gov/pubmed/24758515 http://dx.doi.org/10.1111/bph.12728

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