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The Emergence of Bacterial “Hopeful Monsters”

The global spread of antibiotic-resistant bacteria has largely been driven by the dissemination of successful lineages. A particularly important example is sequence type (ST) 258 of Klebsiella pneumoniae, a common cause of health care-associated infections. Representatives of this lineage carry a va...

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Detalles Bibliográficos
Autores principales: Croucher, Nicholas J., Klugman, Keith P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128365/
https://www.ncbi.nlm.nih.gov/pubmed/25073645
http://dx.doi.org/10.1128/mBio.01550-14
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author Croucher, Nicholas J.
Klugman, Keith P.
author_facet Croucher, Nicholas J.
Klugman, Keith P.
author_sort Croucher, Nicholas J.
collection PubMed
description The global spread of antibiotic-resistant bacteria has largely been driven by the dissemination of successful lineages. A particularly important example is sequence type (ST) 258 of Klebsiella pneumoniae, a common cause of health care-associated infections. Representatives of this lineage carry a variable array of plasmid-borne resistance genes, typically including a carbapenemase effective against the full range of clinically important β-lactams. In their recent mBio article, Chen et al. [mBio 5(3):e01355-14] described how ST258 emerged through “hybridization” between two other strains, with a second recombination resulting in the diversification of a key antigen. This commentary describes the findings in the context of other examples where saltational evolution has resulted in the sudden emergence of important pathogenic bacteria.
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spelling pubmed-41283652014-08-12 The Emergence of Bacterial “Hopeful Monsters” Croucher, Nicholas J. Klugman, Keith P. mBio Commentary The global spread of antibiotic-resistant bacteria has largely been driven by the dissemination of successful lineages. A particularly important example is sequence type (ST) 258 of Klebsiella pneumoniae, a common cause of health care-associated infections. Representatives of this lineage carry a variable array of plasmid-borne resistance genes, typically including a carbapenemase effective against the full range of clinically important β-lactams. In their recent mBio article, Chen et al. [mBio 5(3):e01355-14] described how ST258 emerged through “hybridization” between two other strains, with a second recombination resulting in the diversification of a key antigen. This commentary describes the findings in the context of other examples where saltational evolution has resulted in the sudden emergence of important pathogenic bacteria. American Society of Microbiology 2014-07-29 /pmc/articles/PMC4128365/ /pubmed/25073645 http://dx.doi.org/10.1128/mBio.01550-14 Text en Copyright © 2014 Croucher and Klugman. http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license (http://creativecommons.org/licenses/by-nc-sa/3.0/) , which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Commentary
Croucher, Nicholas J.
Klugman, Keith P.
The Emergence of Bacterial “Hopeful Monsters”
title The Emergence of Bacterial “Hopeful Monsters”
title_full The Emergence of Bacterial “Hopeful Monsters”
title_fullStr The Emergence of Bacterial “Hopeful Monsters”
title_full_unstemmed The Emergence of Bacterial “Hopeful Monsters”
title_short The Emergence of Bacterial “Hopeful Monsters”
title_sort emergence of bacterial “hopeful monsters”
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128365/
https://www.ncbi.nlm.nih.gov/pubmed/25073645
http://dx.doi.org/10.1128/mBio.01550-14
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