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Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice

BACKGROUND: The polarization to different neuroinflammatory phenotypes has been described in early Alzheimer’s disease, yet the impact of these phenotypes on amyloid-beta (Aβ) pathology remains unknown. Short-term studies show that induction of an M1 neuroinflammatory phenotype reduces Aβ, but long-...

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Detalles Bibliográficos
Autores principales:	Weekman, Erica M, Sudduth, Tiffany L, Abner, Erin L, Popa, Gabriel J, Mendenhall, Michael D, Brothers, Holly M, Braun, Kaitlyn, Greenstein, Abigail, Wilcock, Donna M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128532/ https://www.ncbi.nlm.nih.gov/pubmed/25062954 http://dx.doi.org/10.1186/1742-2094-11-127

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