Challenges in predicting the evolutionary maintenance of a phage transgene

BACKGROUND: In prior work, a phage engineered with a biofilm-degrading enzyme (dispersin B) cleared artificial, short-term biofilms more fully than the phage lacking the enzyme. An unresolved question is whether the transgene will be lost or maintained during phage growth – its loss would limit the...

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Detalles Bibliográficos
Autores principales: Schmerer, Matthew, Molineux, Ian J, Ally, Dilara, Tyerman, Jabus, Cecchini, Nicole, Bull, James J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128545/
https://www.ncbi.nlm.nih.gov/pubmed/25126112
http://dx.doi.org/10.1186/1754-1611-8-21

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