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Systemic vascular resistance in cirrhosis: a predictor of severity?
BACKGROUND: The aim of this study was to investigate whether systemic vascular resistance (SVR) correlates with validated prospective scoring systems such as Model for End-stage Liver Disease (MELD) and its modifications. METHODS: Patients with cirrhosis, who were admitted to hospital with decompens...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128691/ https://www.ncbi.nlm.nih.gov/pubmed/25187743 http://dx.doi.org/10.2147/HMER.S67036 |
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author | Gaduputi, Vinaya Abdulsamad, Molham Sakam, Sailaja Abbas, Naeem Tariq, Hassan Ihimoyan, Ariyo |
author_facet | Gaduputi, Vinaya Abdulsamad, Molham Sakam, Sailaja Abbas, Naeem Tariq, Hassan Ihimoyan, Ariyo |
author_sort | Gaduputi, Vinaya |
collection | PubMed |
description | BACKGROUND: The aim of this study was to investigate whether systemic vascular resistance (SVR) correlates with validated prospective scoring systems such as Model for End-stage Liver Disease (MELD) and its modifications. METHODS: Patients with cirrhosis, who were admitted to hospital with decompensation (as defined by development of ascites, hepatic encephalopathy, and variceal bleeding) and underwent echocardiography were included in this study. Laboratory data required for computing MELD score, serum bilirubin, serum creatinine, international normalized ratio, and serum sodium were collected for every patient. We tabulated hemodynamic and echocardiography parameters that enabled calculation of SVR. We analyzed the correlation between SVR and each of the individual prognostic scores. RESULTS: A total of 771 patients with a diagnosis of decompensated cirrhosis were included in the study. Two hundred and sixty-two patients were found to have a low sodium level (<135 mEq/L) and 509 were found to have a normal sodium level (>135 mEq/L). In the patients with hyponatremia, we found statistically significant inverse correlations between SVR and validated liver severity models. However, these correlations were not seen in patients with normonatremia. CONCLUSION: We observed a statistically significant inverse correlation between SVR and all the validated liver disease severity models used in this study among patients with hyponatremia but not in those with normonatremia. |
format | Online Article Text |
id | pubmed-4128691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-41286912014-09-03 Systemic vascular resistance in cirrhosis: a predictor of severity? Gaduputi, Vinaya Abdulsamad, Molham Sakam, Sailaja Abbas, Naeem Tariq, Hassan Ihimoyan, Ariyo Hepat Med Original Research BACKGROUND: The aim of this study was to investigate whether systemic vascular resistance (SVR) correlates with validated prospective scoring systems such as Model for End-stage Liver Disease (MELD) and its modifications. METHODS: Patients with cirrhosis, who were admitted to hospital with decompensation (as defined by development of ascites, hepatic encephalopathy, and variceal bleeding) and underwent echocardiography were included in this study. Laboratory data required for computing MELD score, serum bilirubin, serum creatinine, international normalized ratio, and serum sodium were collected for every patient. We tabulated hemodynamic and echocardiography parameters that enabled calculation of SVR. We analyzed the correlation between SVR and each of the individual prognostic scores. RESULTS: A total of 771 patients with a diagnosis of decompensated cirrhosis were included in the study. Two hundred and sixty-two patients were found to have a low sodium level (<135 mEq/L) and 509 were found to have a normal sodium level (>135 mEq/L). In the patients with hyponatremia, we found statistically significant inverse correlations between SVR and validated liver severity models. However, these correlations were not seen in patients with normonatremia. CONCLUSION: We observed a statistically significant inverse correlation between SVR and all the validated liver disease severity models used in this study among patients with hyponatremia but not in those with normonatremia. Dove Medical Press 2014-08-06 /pmc/articles/PMC4128691/ /pubmed/25187743 http://dx.doi.org/10.2147/HMER.S67036 Text en © 2014 Gaduputi et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Gaduputi, Vinaya Abdulsamad, Molham Sakam, Sailaja Abbas, Naeem Tariq, Hassan Ihimoyan, Ariyo Systemic vascular resistance in cirrhosis: a predictor of severity? |
title | Systemic vascular resistance in cirrhosis: a predictor of severity? |
title_full | Systemic vascular resistance in cirrhosis: a predictor of severity? |
title_fullStr | Systemic vascular resistance in cirrhosis: a predictor of severity? |
title_full_unstemmed | Systemic vascular resistance in cirrhosis: a predictor of severity? |
title_short | Systemic vascular resistance in cirrhosis: a predictor of severity? |
title_sort | systemic vascular resistance in cirrhosis: a predictor of severity? |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128691/ https://www.ncbi.nlm.nih.gov/pubmed/25187743 http://dx.doi.org/10.2147/HMER.S67036 |
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