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Pleiotropic Functions for Transcription Factor Zscan10
The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo. Mice homozygous for a Zscan10 m...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128777/ https://www.ncbi.nlm.nih.gov/pubmed/25111779 http://dx.doi.org/10.1371/journal.pone.0104568 |
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| author | Kraus, Petra V, Sivakamasundari Yu, Hong Bing Xing, Xing Lim, Siew Lan Adler, Thure Pimentel, Juan Antonio Aguilar Becker, Lore Bohla, Alexander Garrett, Lillian Hans, Wolfgang Hölter, Sabine M. Janas, Eva Moreth, Kristin Prehn, Cornelia Puk, Oliver Rathkolb, Birgit Rozman, Jan Adamski, Jerzy Bekeredjian, Raffi Busch, Dirk H. Graw, Jochen Klingenspor, Martin Klopstock, Thomas Neff, Frauke Ollert, Markus Stoeger, Tobias Yildrim, Ali Önder Eickelberg, Oliver Wolf, Eckhard Wurst, Wolfgang Fuchs, Helmut Gailus-Durner, Valérie de Angelis, Martin Hrabě Lufkin, Thomas Stanton, Lawrence W. |
| author_facet | Kraus, Petra V, Sivakamasundari Yu, Hong Bing Xing, Xing Lim, Siew Lan Adler, Thure Pimentel, Juan Antonio Aguilar Becker, Lore Bohla, Alexander Garrett, Lillian Hans, Wolfgang Hölter, Sabine M. Janas, Eva Moreth, Kristin Prehn, Cornelia Puk, Oliver Rathkolb, Birgit Rozman, Jan Adamski, Jerzy Bekeredjian, Raffi Busch, Dirk H. Graw, Jochen Klingenspor, Martin Klopstock, Thomas Neff, Frauke Ollert, Markus Stoeger, Tobias Yildrim, Ali Önder Eickelberg, Oliver Wolf, Eckhard Wurst, Wolfgang Fuchs, Helmut Gailus-Durner, Valérie de Angelis, Martin Hrabě Lufkin, Thomas Stanton, Lawrence W. |
| author_sort | Kraus, Petra |
| collection | PubMed |
| description | The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo. Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye malformation previously described for Sox2 hypomorphs. Phenotypic abnormalities are supported by the nature of Zscan10 expression in midgestation embryos and adults suggesting a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof. |
| format | Online Article Text |
| id | pubmed-4128777 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-41287772014-08-12 Pleiotropic Functions for Transcription Factor Zscan10 Kraus, Petra V, Sivakamasundari Yu, Hong Bing Xing, Xing Lim, Siew Lan Adler, Thure Pimentel, Juan Antonio Aguilar Becker, Lore Bohla, Alexander Garrett, Lillian Hans, Wolfgang Hölter, Sabine M. Janas, Eva Moreth, Kristin Prehn, Cornelia Puk, Oliver Rathkolb, Birgit Rozman, Jan Adamski, Jerzy Bekeredjian, Raffi Busch, Dirk H. Graw, Jochen Klingenspor, Martin Klopstock, Thomas Neff, Frauke Ollert, Markus Stoeger, Tobias Yildrim, Ali Önder Eickelberg, Oliver Wolf, Eckhard Wurst, Wolfgang Fuchs, Helmut Gailus-Durner, Valérie de Angelis, Martin Hrabě Lufkin, Thomas Stanton, Lawrence W. PLoS One Research Article The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo. Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye malformation previously described for Sox2 hypomorphs. Phenotypic abnormalities are supported by the nature of Zscan10 expression in midgestation embryos and adults suggesting a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof. Public Library of Science 2014-08-11 /pmc/articles/PMC4128777/ /pubmed/25111779 http://dx.doi.org/10.1371/journal.pone.0104568 Text en © 2014 Kraus et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| spellingShingle | Research Article Kraus, Petra V, Sivakamasundari Yu, Hong Bing Xing, Xing Lim, Siew Lan Adler, Thure Pimentel, Juan Antonio Aguilar Becker, Lore Bohla, Alexander Garrett, Lillian Hans, Wolfgang Hölter, Sabine M. Janas, Eva Moreth, Kristin Prehn, Cornelia Puk, Oliver Rathkolb, Birgit Rozman, Jan Adamski, Jerzy Bekeredjian, Raffi Busch, Dirk H. Graw, Jochen Klingenspor, Martin Klopstock, Thomas Neff, Frauke Ollert, Markus Stoeger, Tobias Yildrim, Ali Önder Eickelberg, Oliver Wolf, Eckhard Wurst, Wolfgang Fuchs, Helmut Gailus-Durner, Valérie de Angelis, Martin Hrabě Lufkin, Thomas Stanton, Lawrence W. Pleiotropic Functions for Transcription Factor Zscan10 |
| title | Pleiotropic Functions for Transcription Factor Zscan10 |
| title_full | Pleiotropic Functions for Transcription Factor Zscan10 |
| title_fullStr | Pleiotropic Functions for Transcription Factor Zscan10 |
| title_full_unstemmed | Pleiotropic Functions for Transcription Factor Zscan10 |
| title_short | Pleiotropic Functions for Transcription Factor Zscan10 |
| title_sort | pleiotropic functions for transcription factor zscan10 |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128777/ https://www.ncbi.nlm.nih.gov/pubmed/25111779 http://dx.doi.org/10.1371/journal.pone.0104568 |
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