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A community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype

BACKGROUND: Lower habitual physical activity and poor cardiorespiratory fitness are common features of the metabolically abnormal obese (MAO) phenotype that contribute to increased cardiovascular disease risk. The aims of the present study were to determine 1) whether community-based exercise traini...

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Autores principales: Dalleck, Lance C, Van Guilder, Gary P, Richardson, Tara B, Bredle, Donald L, Janot, Jeffrey M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128798/
https://www.ncbi.nlm.nih.gov/pubmed/25120373
http://dx.doi.org/10.2147/DMSO.S67441
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author Dalleck, Lance C
Van Guilder, Gary P
Richardson, Tara B
Bredle, Donald L
Janot, Jeffrey M
author_facet Dalleck, Lance C
Van Guilder, Gary P
Richardson, Tara B
Bredle, Donald L
Janot, Jeffrey M
author_sort Dalleck, Lance C
collection PubMed
description BACKGROUND: Lower habitual physical activity and poor cardiorespiratory fitness are common features of the metabolically abnormal obese (MAO) phenotype that contribute to increased cardiovascular disease risk. The aims of the present study were to determine 1) whether community-based exercise training transitions MAO adults to metabolically healthy, and 2) whether the odds of transition to metabolically healthy were larger for obese individuals who performed higher volumes of exercise and/or experienced greater increases in fitness. METHODS AND RESULTS: Metabolic syndrome components were measured in 332 adults (190 women, 142 men) before and after a supervised 14-week community-based exercise program designed to reduce cardiometabolic risk factors. Obese (body mass index ≥30 kg · m(2)) adults with two to four metabolic syndrome components were classified as MAO, whereas those with no or one component were classified as metabolically healthy but obese (MHO). After community exercise, 27/68 (40%) MAO individuals (P<0.05) transitioned to metabolically healthy, increasing the total number of MHO persons by 73% (from 37 to 64). Compared with the lowest quartiles of relative energy expenditure and change in fitness, participants in the highest quartiles were 11.6 (95% confidence interval: 2.1–65.4; P<0.05) and 7.5 (95% confidence interval: 1.5–37.5; P<0.05) times more likely to transition from MAO to MHO, respectively. CONCLUSION: Community-based exercise transitions MAO adults to metabolically healthy. MAO adults who engaged in higher volumes of exercise and experienced the greatest increase in fitness were significantly more likely to become metabolically healthy. Community exercise may be an effective model for primary prevention of cardiovascular disease.
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spelling pubmed-41287982014-08-12 A community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype Dalleck, Lance C Van Guilder, Gary P Richardson, Tara B Bredle, Donald L Janot, Jeffrey M Diabetes Metab Syndr Obes Original Research BACKGROUND: Lower habitual physical activity and poor cardiorespiratory fitness are common features of the metabolically abnormal obese (MAO) phenotype that contribute to increased cardiovascular disease risk. The aims of the present study were to determine 1) whether community-based exercise training transitions MAO adults to metabolically healthy, and 2) whether the odds of transition to metabolically healthy were larger for obese individuals who performed higher volumes of exercise and/or experienced greater increases in fitness. METHODS AND RESULTS: Metabolic syndrome components were measured in 332 adults (190 women, 142 men) before and after a supervised 14-week community-based exercise program designed to reduce cardiometabolic risk factors. Obese (body mass index ≥30 kg · m(2)) adults with two to four metabolic syndrome components were classified as MAO, whereas those with no or one component were classified as metabolically healthy but obese (MHO). After community exercise, 27/68 (40%) MAO individuals (P<0.05) transitioned to metabolically healthy, increasing the total number of MHO persons by 73% (from 37 to 64). Compared with the lowest quartiles of relative energy expenditure and change in fitness, participants in the highest quartiles were 11.6 (95% confidence interval: 2.1–65.4; P<0.05) and 7.5 (95% confidence interval: 1.5–37.5; P<0.05) times more likely to transition from MAO to MHO, respectively. CONCLUSION: Community-based exercise transitions MAO adults to metabolically healthy. MAO adults who engaged in higher volumes of exercise and experienced the greatest increase in fitness were significantly more likely to become metabolically healthy. Community exercise may be an effective model for primary prevention of cardiovascular disease. Dove Medical Press 2014-08-01 /pmc/articles/PMC4128798/ /pubmed/25120373 http://dx.doi.org/10.2147/DMSO.S67441 Text en © 2014 Dalleck et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Dalleck, Lance C
Van Guilder, Gary P
Richardson, Tara B
Bredle, Donald L
Janot, Jeffrey M
A community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype
title A community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype
title_full A community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype
title_fullStr A community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype
title_full_unstemmed A community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype
title_short A community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype
title_sort community-based exercise intervention transitions metabolically abnormal obese adults to a metabolically healthy obese phenotype
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128798/
https://www.ncbi.nlm.nih.gov/pubmed/25120373
http://dx.doi.org/10.2147/DMSO.S67441
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