Cargando…

Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application

We propose a strategy for optimizing distribution of flow in a typical benchtop microfluidic chamber for dielectrophoretic application. It is aimed at encouraging uniform flow velocity along the whole analysis chamber in order to ensure DEP force is evenly applied to biological particle. Via the stu...

Descripción completa

Detalles Bibliográficos
Autores principales: Low, Wan Shi, Kadri, Nahrizul Adib, Wan Abas, Wan Abu Bakar bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129156/
https://www.ncbi.nlm.nih.gov/pubmed/25136701
http://dx.doi.org/10.1155/2014/961301
_version_ 1782330205458661376
author Low, Wan Shi
Kadri, Nahrizul Adib
Wan Abas, Wan Abu Bakar bin
author_facet Low, Wan Shi
Kadri, Nahrizul Adib
Wan Abas, Wan Abu Bakar bin
author_sort Low, Wan Shi
collection PubMed
description We propose a strategy for optimizing distribution of flow in a typical benchtop microfluidic chamber for dielectrophoretic application. It is aimed at encouraging uniform flow velocity along the whole analysis chamber in order to ensure DEP force is evenly applied to biological particle. Via the study, we have come up with a constructive strategy in improving the design of microfluidic channel which will greatly facilitate the use of DEP system in laboratory and primarily focus on the relationship between architecture and cell distribution, by resorting to the tubular structure of blood vessels. The design was validated by hydrodynamic flow simulation using COMSOL Multiphysics v4.2a software. Simulations show that the presence of 2-level bifurcation has developed portioning of volumetric flow which produced uniform flow across the channel. However, further bifurcation will reduce the volumetric flow rate, thus causing undesirable deposition of cell suspension around the chamber. Finally, an improvement of microfluidic design with rounded corner is proposed to encourage a uniform cell adhesion within the channel.
format Online
Article
Text
id pubmed-4129156
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-41291562014-08-18 Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application Low, Wan Shi Kadri, Nahrizul Adib Wan Abas, Wan Abu Bakar bin ScientificWorldJournal Research Article We propose a strategy for optimizing distribution of flow in a typical benchtop microfluidic chamber for dielectrophoretic application. It is aimed at encouraging uniform flow velocity along the whole analysis chamber in order to ensure DEP force is evenly applied to biological particle. Via the study, we have come up with a constructive strategy in improving the design of microfluidic channel which will greatly facilitate the use of DEP system in laboratory and primarily focus on the relationship between architecture and cell distribution, by resorting to the tubular structure of blood vessels. The design was validated by hydrodynamic flow simulation using COMSOL Multiphysics v4.2a software. Simulations show that the presence of 2-level bifurcation has developed portioning of volumetric flow which produced uniform flow across the channel. However, further bifurcation will reduce the volumetric flow rate, thus causing undesirable deposition of cell suspension around the chamber. Finally, an improvement of microfluidic design with rounded corner is proposed to encourage a uniform cell adhesion within the channel. Hindawi Publishing Corporation 2014 2014-07-20 /pmc/articles/PMC4129156/ /pubmed/25136701 http://dx.doi.org/10.1155/2014/961301 Text en Copyright © 2014 Wan Shi Low et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Low, Wan Shi
Kadri, Nahrizul Adib
Wan Abas, Wan Abu Bakar bin
Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application
title Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application
title_full Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application
title_fullStr Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application
title_full_unstemmed Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application
title_short Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application
title_sort computational fluid dynamics modelling of microfluidic channel for dielectrophoretic biomems application
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129156/
https://www.ncbi.nlm.nih.gov/pubmed/25136701
http://dx.doi.org/10.1155/2014/961301
work_keys_str_mv AT lowwanshi computationalfluiddynamicsmodellingofmicrofluidicchannelfordielectrophoreticbiomemsapplication
AT kadrinahrizuladib computationalfluiddynamicsmodellingofmicrofluidicchannelfordielectrophoreticbiomemsapplication
AT wanabaswanabubakarbin computationalfluiddynamicsmodellingofmicrofluidicchannelfordielectrophoreticbiomemsapplication