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Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application
We propose a strategy for optimizing distribution of flow in a typical benchtop microfluidic chamber for dielectrophoretic application. It is aimed at encouraging uniform flow velocity along the whole analysis chamber in order to ensure DEP force is evenly applied to biological particle. Via the stu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129156/ https://www.ncbi.nlm.nih.gov/pubmed/25136701 http://dx.doi.org/10.1155/2014/961301 |
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author | Low, Wan Shi Kadri, Nahrizul Adib Wan Abas, Wan Abu Bakar bin |
author_facet | Low, Wan Shi Kadri, Nahrizul Adib Wan Abas, Wan Abu Bakar bin |
author_sort | Low, Wan Shi |
collection | PubMed |
description | We propose a strategy for optimizing distribution of flow in a typical benchtop microfluidic chamber for dielectrophoretic application. It is aimed at encouraging uniform flow velocity along the whole analysis chamber in order to ensure DEP force is evenly applied to biological particle. Via the study, we have come up with a constructive strategy in improving the design of microfluidic channel which will greatly facilitate the use of DEP system in laboratory and primarily focus on the relationship between architecture and cell distribution, by resorting to the tubular structure of blood vessels. The design was validated by hydrodynamic flow simulation using COMSOL Multiphysics v4.2a software. Simulations show that the presence of 2-level bifurcation has developed portioning of volumetric flow which produced uniform flow across the channel. However, further bifurcation will reduce the volumetric flow rate, thus causing undesirable deposition of cell suspension around the chamber. Finally, an improvement of microfluidic design with rounded corner is proposed to encourage a uniform cell adhesion within the channel. |
format | Online Article Text |
id | pubmed-4129156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41291562014-08-18 Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application Low, Wan Shi Kadri, Nahrizul Adib Wan Abas, Wan Abu Bakar bin ScientificWorldJournal Research Article We propose a strategy for optimizing distribution of flow in a typical benchtop microfluidic chamber for dielectrophoretic application. It is aimed at encouraging uniform flow velocity along the whole analysis chamber in order to ensure DEP force is evenly applied to biological particle. Via the study, we have come up with a constructive strategy in improving the design of microfluidic channel which will greatly facilitate the use of DEP system in laboratory and primarily focus on the relationship between architecture and cell distribution, by resorting to the tubular structure of blood vessels. The design was validated by hydrodynamic flow simulation using COMSOL Multiphysics v4.2a software. Simulations show that the presence of 2-level bifurcation has developed portioning of volumetric flow which produced uniform flow across the channel. However, further bifurcation will reduce the volumetric flow rate, thus causing undesirable deposition of cell suspension around the chamber. Finally, an improvement of microfluidic design with rounded corner is proposed to encourage a uniform cell adhesion within the channel. Hindawi Publishing Corporation 2014 2014-07-20 /pmc/articles/PMC4129156/ /pubmed/25136701 http://dx.doi.org/10.1155/2014/961301 Text en Copyright © 2014 Wan Shi Low et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Low, Wan Shi Kadri, Nahrizul Adib Wan Abas, Wan Abu Bakar bin Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application |
title | Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application |
title_full | Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application |
title_fullStr | Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application |
title_full_unstemmed | Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application |
title_short | Computational Fluid Dynamics Modelling of Microfluidic Channel for Dielectrophoretic BioMEMS Application |
title_sort | computational fluid dynamics modelling of microfluidic channel for dielectrophoretic biomems application |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129156/ https://www.ncbi.nlm.nih.gov/pubmed/25136701 http://dx.doi.org/10.1155/2014/961301 |
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