Acute Pancreatitis Induced by Methimazole Treatment in a 51-Year-Old Korean Man: A Case Report

Methimazole (MMI)-induced acute pancreatitis is very rare but severe adverse reaction. A 51-yr-old male developed a high fever, chills, and abdominal pain, two weeks after commencement on MMI for the treatment of Graves' disease. There was no evidence of agranulocytosis, and fever subsided soon...

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Detalles Bibliográficos
Autores principales: Jung, Jung Hwa, Hahm, Jong Ryeal, Jung, Jaehoon, Kim, Soo Kyoung, Kim, Sungsu, Kim, Kyong Young, Kim, Bo Ra, Kim, Hong Jun, Jeong, Yi Yeong, Kim, Sun Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129213/
https://www.ncbi.nlm.nih.gov/pubmed/25120331
http://dx.doi.org/10.3346/jkms.2014.29.8.1170
Descripción
Sumario:Methimazole (MMI)-induced acute pancreatitis is very rare but severe adverse reaction. A 51-yr-old male developed a high fever, chills, and abdominal pain, two weeks after commencement on MMI for the treatment of Graves' disease. There was no evidence of agranulocytosis, and fever subsided soon after stopping MMI treatment. However, 5 hr after taking an additional dose of MMI, abdominal pain and fever developed again. His symptoms, biochemical, and imaging studies were compatible with acute pancreatitis. After withdrawal of MMI, he showed clinical improvement. This is the first case of MMI-induced acute pancreatitis in Korea. Clinicians should be aware of the rare but possible MMI-induced pancreatitis in patients complaining of fever and abdominal pain. GRAPHICAL ABSTRACT: [Image: see text]

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