Cargando…

Identification and Validation of Genetic Variants that Influence Transcription Factor and Cell Signaling Protein Levels

Many genetic variants associated with human disease have been found to be associated with alterations in mRNA expression. Although it is commonly assumed that mRNA expression changes will lead to consequent changes in protein levels, methodological challenges have limited our ability to test the deg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hause, Ronald J., Stark, Amy L., Antao, Nirav N., Gorsic, Lidija K., Chung, Sophie H., Brown, Christopher D., Wong, Shan S., Gill, Daniel F., Myers, Jamie L., To, Lida Anita, White, Kevin P., Dolan, M. Eileen, Jones, Richard Baker
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129400/ https://www.ncbi.nlm.nih.gov/pubmed/25087611 http://dx.doi.org/10.1016/j.ajhg.2014.07.005

Ejemplares similares

Protein Quantitative Trait Loci Identify Novel Candidates Modulating Cellular Response to Chemotherapy
por: Stark, Amy L., et al.
Publicado: (2014)

EPS8 Inhibition Increases Cisplatin Sensitivity in Lung Cancer Cells
por: Gorsic, Lidija K., et al.
Publicado: (2013)

Genome-Wide Local Ancestry Approach Identifies Genes and Variants Associated with Chemotherapeutic Susceptibility in African Americans
por: Wheeler, Heather E., et al.
Publicado: (2011)

Genome-wide Meta-analysis Identifies Variants Associated with Platinating Agent Susceptibility Across Populations
por: Wheeler, Heather E., et al.
Publicado: (2011)

Integrating Cell-Based and Clinical Genome-Wide Studies to Identify Genetic Variants Contributing to Treatment Failure in Neuroblastoma Patients
por: Pinto, Navin, et al.
Publicado: (2014)

Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach
por: Eadon, Michael T., et al.
Publicado: (2017)

FRI458 Rare Pathogenic Missense Variants in LMNA Identified in Women with Polycystic Ovary Syndrome (PCOS)
por: Bauer, Rosemary, et al.
Publicado: (2023)

Mixed Effects Modeling of Proliferation Rates in Cell-Based Models: Consequence for Pharmacogenomics and Cancer
por: Im, Hae Kyung, et al.
Publicado: (2012)

20 years of daily hospital for non-psychotic disorders, organisational structure and treatment modalities
por: Caratan, S., et al.
Publicado: (2022)

Adrenal Angiosarcoma: A Diagnostic Dilemma
por: Antao, Nirav, et al.
Publicado: (2019)

Competitive and cooperative arm rehabilitation games played by a patient and unimpaired person: effects on motivation and exercise intensity
por: Goršič, Maja, et al.
Publicado: (2017)

Load Position and Weight Classification during Carrying Gait Using Wearable Inertial and Electromyographic Sensors
por: Goršič, Maja, et al.
Publicado: (2020)

Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus
por: Yang, Rui, et al.
Publicado: (2016)

Toward Real-Time Automated Detection of Turns during Gait Using Wearable Inertial Measurement Units
por: Novak, Domen, et al.
Publicado: (2014)

A multisession evaluation of an adaptive competitive arm rehabilitation game
por: Goršič, Maja, et al.
Publicado: (2017)

Variants Affecting Exon Skipping Contribute to Complex Traits
por: Lee, Younghee, et al.
Publicado: (2012)

Senecavirus A in Pigs, United States, 2015
por: Hause, Ben M., et al.
Publicado: (2016)

A Brief Measure of Interpersonal Interaction for 2-Player Serious Games: Questionnaire Validation
por: Gorsic, Maja, et al.
Publicado: (2019)

Automatic Estimation of Interpersonal Engagement During Naturalistic Conversation Using Dyadic Physiological Measurements
por: Chatterjee, Iman, et al.
Publicado: (2021)

Natural Genetic Variation for Growth and Development Revealed by High-Throughput Phenotyping in Arabidopsis thaliana
por: Zhang, Xu, et al.
Publicado: (2012)

Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions
por: Gray, Vanessa E., et al.
Publicado: (2017)

Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant
por: Lopez Bernal, Jamie, et al.
Publicado: (2021)

Global Analysis of Plasmodium falciparum Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study
por: Boateng, Rita Afriyie, et al.
Publicado: (2022)

MRSA Variant in Companion Animals
por: Walther, Birgit, et al.
Publicado: (2012)

Structure and function of the divalent anion/Na(+) symporter from Vibrio cholerae and a humanized variant
por: Nie, Rongxin, et al.
Publicado: (2017)

Analyzing the soybean transcriptome during autoregulation of mycorrhization identifies the transcription factors GmNF-YA1a/b as positive regulators of arbuscular mycorrhization
por: Schaarschmidt, Sara, et al.
Publicado: (2013)

The ‘Candidatus Phytoplasma mali’ effector protein SAP11(CaPm) interacts with MdTCP16, a class II CYC/TB1 transcription factor that is highly expressed during phytoplasma infection
por: Mittelberger, Cecilia, et al.
Publicado: (2022)

On the challenges of the HapMap resource
por: Zhang, Wei, et al.
Publicado: (2008)

Exploring the Evolutionary History of the Differentially Expressed Genes between Human Populations: Action of Recent Positive Selection
por: Zhang, Wei, et al.
Publicado: (2008)

Recent Emergence of Bovine Coronavirus Variants with Mutations in the Hemagglutinin-Esterase Receptor Binding Domain in U.S. Cattle
por: Workman, Aspen M., et al.
Publicado: (2022)

The effectiveness of nab-paclitaxel plus gemcitabine and gemcitabine monotherapy in first-line metastatic pancreatic cancer treatment: A real-world evidence
por: Prejac, Juraj, et al.
Publicado: (2022)

An inactivated influenza D virus vaccine partially protects cattle from respiratory disease caused by homologous challenge
por: Hause, Ben M., et al.
Publicado: (2017)

Menstrual irregularities and vaginal bleeding after COVID-19 vaccination reported to v-safe active surveillance, USA in December, 2020–January, 2022: an observational cohort study
por: Wong, Karen K, et al.
Publicado: (2022)

Multiplex Assessment of Protein Variant Abundance by Massively Parallel Sequencing
por: Matreyek, Kenneth A., et al.
Publicado: (2018)

Relationship between TP53 and interleukin-6 gene variants and the risk of types 1 and 2 diabetes mellitus development in the Kermanshah province
por: Haghnazari, Lida, et al.
Publicado: (2021)

Online Phase Detection Using Wearable Sensors for Walking with a Robotic Prosthesis
por: Goršič, Maja, et al.
Publicado: (2014)

RegSNPs-intron: a computational framework for predicting pathogenic impact of intronic single nucleotide variants
por: Lin, Hai, et al.
Publicado: (2019)

Pharmacogenomics of chemotherapeutic susceptibility and toxicity
por: Moen, Erika L, et al.
Publicado: (2012)

Composite Medicago truncatula plants harbouring Agrobacterium rhizogenes-transformed roots reveal normal mycorrhization by Glomus intraradices
por: Mrosk, Cornelia, et al.
Publicado: (2009)

Hospitalization and Mortality Risk for COVID-19 Cases With SARS-CoV-2 AY.4.2 (VUI-21OCT-01) Compared to Non-AY.4.2 Delta Variant Sublineages( )
por: Nyberg, Tommy, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ujjpu4bnt038mdnkhlf1vddm9n