Cargando…

FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells

Cell migration requires the fine spatiotemporal integration of many proteins that regulate the fundamental processes that drive cell movement. Focal adhesion (FA) dynamics is a continuous process involving coordination between FA and actin cytoskeleton, which is essential for cell migration. We stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Ying-Li, Lu, Shaoying, Szeto, Kai W., Sun, Jie, Wang, Yingxiao, Lasheras, Juan C., Chien, Shu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129417/ https://www.ncbi.nlm.nih.gov/pubmed/25113375 http://dx.doi.org/10.1038/srep06024

Ejemplares similares

Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart
por: Hirth, Sofia, et al.
Publicado: (2016)

Direct association of pp125FAK with paxillin, the focal adhesion- targeting mechanism of pp125FAK
Publicado: (1995)

FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
por: Schaller, Michael D.
Publicado: (2004)

Altering FAK-Paxillin Interactions Reduces Adhesion, Migration and Invasion Processes
por: Deramaudt, Thérèse B., et al.
Publicado: (2014)

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation
por: Pasapera, Ana M., et al.
Publicado: (2010)

Rap1 Can Bypass the FAK-Src-Paxillin Cascade to Induce Cell Spreading and Focal Adhesion Formation
por: Ross, Sarah H., et al.
Publicado: (2012)

Nudel and FAK as Antagonizing Strength Modulators of Nascent Adhesions through Paxillin
por: Shan, Yongli, et al.
Publicado: (2009)

Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains
por: Sathe, Aneesh R., et al.
Publicado: (2016)

FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion
por: Deramaudt, Therese B., et al.
Publicado: (2011)

In-situ coupling between kinase activities and protein dynamics within single focal adhesions
por: Wu, Yiqian, et al.
Publicado: (2016)

Focal adhesion kinase and paxillin promote migration and adhesion to fibronectin by swine skeletal muscle satellite cells
por: Wang, Dan, et al.
Publicado: (2016)

Degraded Collagen Fragments Promote Rapid Disassembly of Smooth Muscle Focal Adhesions That Correlates with Cleavage of Pp125(FAK), Paxillin, and Talin
por: Carragher, Neil O., et al.
Publicado: (1999)

Paxillin phosphorylation at Ser273 localizes a GIT1–PIX–PAK complex and regulates adhesion and protrusion dynamics
por: Nayal, Anjana, et al.
Publicado: (2006)

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding
Publicado: (1996)

Dynamics and distribution of paxillin, vinculin, zyxin and VASP depend on focal adhesion location and orientation
por: Legerstee, Karin, et al.
Publicado: (2019)

Ganoderiol A-Enriched Extract Suppresses Migration and Adhesion of MDA-MB-231 Cells by Inhibiting FAK-SRC-Paxillin Cascade Pathway
por: Wu, Guo-Sheng, et al.
Publicado: (2013)

Multiple paxillin binding sites regulate FAK function
por: Scheswohl, Danielle M, et al.
Publicado: (2008)

FAK and paxillin, two potential targets in pancreatic cancer
por: Kanteti, Rajani, et al.
Publicado: (2016)

Cortactin as a Target for FAK in the Regulation of Focal Adhesion Dynamics
por: Tomar, Alok, et al.
Publicado: (2012)

Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells
por: Lu, Shaoying, et al.
Publicado: (2014)

Paxillin: a new vinculin-binding protein present in focal adhesions
Publicado: (1990)

Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: Relevance to lung cancer
por: Kawada, Ichiro, et al.
Publicado: (2013)

Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin
por: Rondas, Dieter, et al.
Publicado: (2011)

Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts
por: Totsukawa, Go, et al.
Publicado: (2004)

Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion
por: Sachdev, Sanjay, et al.
Publicado: (2009)

Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma cells via the FAK/paxillin and MAPK pathways
por: Cui, Shuna, et al.
Publicado: (2017)

Quercetin inhibits LPS-induced macrophage migration by suppressing the iNOS/FAK/paxillin pathway and modulating the cytoskeleton
por: Cui, Shuna, et al.
Publicado: (2018)

Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion in Microenvironment
por: Zhuo, Yue, et al.
Publicado: (2015)

Inhibiting FAK–Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells
por: Mousson, Antoine, et al.
Publicado: (2021)

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains
Publicado: (1995)

CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation
por: Lu, Shiqi, et al.
Publicado: (2023)

cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: Effects of PKA and EPAC()
por: Burdyga, Alex, et al.
Publicado: (2013)

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly
Publicado: (1992)

Cytosolic phospholipase A2α modulates cell-matrix adhesion via the FAK/paxillin pathway in hepatocellular carcinoma
por: Guo, Piao, et al.
Publicado: (2019)

Actopaxin, a New Focal Adhesion Protein That Binds Paxillin Ld Motifs and Actin and Regulates Cell Adhesion
por: Nikolopoulos, Sotiris N., et al.
Publicado: (2000)

FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion
por: Chan, Keefe T., et al.
Publicado: (2009)

Vinculin modulation of paxillin–FAK interactions regulates ERK to control survival and motility
por: Subauste, M. Cecilia, et al.
Publicado: (2004)

SphK1‐driven autophagy potentiates focal adhesion paxillin‐mediated metastasis in colorectal cancer
por: Wu, Jiang‐Ni, et al.
Publicado: (2021)

Hyperphosphorylated FAK Delocalizes from Focal Adhesions to Membrane Ruffles
por: Hamadi, Abdelkader, et al.
Publicado: (2010)

FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions
por: Tapial Martínez, Paula, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fougjm15st39kn75tqgpi7m682