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The association of vitamin D deficiency with non-alcoholic fatty liver disease
OBJECTIVE: Vitamin D deficiency has been related to diabetes, hypertension, hyperlipidemia and peripheral vascular disease. In this study, we aimed to investigate the role of vitamin D status in non-alcoholic fatty liver disease. METHODS: We included 211 consecutive subjects to examine the presence...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129561/ https://www.ncbi.nlm.nih.gov/pubmed/25141113 http://dx.doi.org/10.6061/clinics/2014(08)07 |
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author | Küçükazman, Metin Ata, Naim Dal, Kürşat Yeniova, Abdullah Özgür Kefeli, Ayşe Basyigit, Sebahat Aktas, Bora Akin, Kadir Okhan Ağladioğlu, Kadir Üre, Öznur Sari Topal, Firdes Nazligül, Yaşar Beyan, Esin Ertugrul, Derun Taner |
author_facet | Küçükazman, Metin Ata, Naim Dal, Kürşat Yeniova, Abdullah Özgür Kefeli, Ayşe Basyigit, Sebahat Aktas, Bora Akin, Kadir Okhan Ağladioğlu, Kadir Üre, Öznur Sari Topal, Firdes Nazligül, Yaşar Beyan, Esin Ertugrul, Derun Taner |
author_sort | Küçükazman, Metin |
collection | PubMed |
description | OBJECTIVE: Vitamin D deficiency has been related to diabetes, hypertension, hyperlipidemia and peripheral vascular disease. In this study, we aimed to investigate the role of vitamin D status in non-alcoholic fatty liver disease. METHODS: We included 211 consecutive subjects to examine the presence of non-alcoholic fatty liver disease. Of these subjects, 57 did not have non-alcoholic fatty liver disease and 154 had non-alcoholic fatty liver disease. RESULTS: The non-alcoholic fatty liver disease group had significantly higher fasting blood glucose (p = 0.005), uric acid (p = 0.001), aspartate aminotransferase (p<0.001), alanine aminotransferase (p<0.001), γ-glutamyltransferase (p<0.0001), alkaline phosphatase (p = 0.028), HbA1c (p<0.001), ferritin (p<0.001), insulin (p = 0.016), C-peptide (p = 0.001), HOMA-IR (p = 0.003), total cholesterol (p = 0.001), triglyceride (p = 0.001) and white blood cell (p = 0.04) levels. In contrast, the non-alcoholic fatty liver disease group had significantly lower 25(OH)D levels (12.3±8.9 ng/dl, p<0.001) compared with those of the control group (20±13.6 ng/dl). CONCLUSIONS: In this study, we found lower serum 25(OH)D levels in patients with non-alcoholic fatty liver disease than in subjects without non-alcoholic fatty liver disease. To establish causality between vitamin D and non-alcoholic fatty liver disease, further interventional studies with a long-term follow-up are needed. |
format | Online Article Text |
id | pubmed-4129561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-41295612014-08-12 The association of vitamin D deficiency with non-alcoholic fatty liver disease Küçükazman, Metin Ata, Naim Dal, Kürşat Yeniova, Abdullah Özgür Kefeli, Ayşe Basyigit, Sebahat Aktas, Bora Akin, Kadir Okhan Ağladioğlu, Kadir Üre, Öznur Sari Topal, Firdes Nazligül, Yaşar Beyan, Esin Ertugrul, Derun Taner Clinics (Sao Paulo) Clinical Science OBJECTIVE: Vitamin D deficiency has been related to diabetes, hypertension, hyperlipidemia and peripheral vascular disease. In this study, we aimed to investigate the role of vitamin D status in non-alcoholic fatty liver disease. METHODS: We included 211 consecutive subjects to examine the presence of non-alcoholic fatty liver disease. Of these subjects, 57 did not have non-alcoholic fatty liver disease and 154 had non-alcoholic fatty liver disease. RESULTS: The non-alcoholic fatty liver disease group had significantly higher fasting blood glucose (p = 0.005), uric acid (p = 0.001), aspartate aminotransferase (p<0.001), alanine aminotransferase (p<0.001), γ-glutamyltransferase (p<0.0001), alkaline phosphatase (p = 0.028), HbA1c (p<0.001), ferritin (p<0.001), insulin (p = 0.016), C-peptide (p = 0.001), HOMA-IR (p = 0.003), total cholesterol (p = 0.001), triglyceride (p = 0.001) and white blood cell (p = 0.04) levels. In contrast, the non-alcoholic fatty liver disease group had significantly lower 25(OH)D levels (12.3±8.9 ng/dl, p<0.001) compared with those of the control group (20±13.6 ng/dl). CONCLUSIONS: In this study, we found lower serum 25(OH)D levels in patients with non-alcoholic fatty liver disease than in subjects without non-alcoholic fatty liver disease. To establish causality between vitamin D and non-alcoholic fatty liver disease, further interventional studies with a long-term follow-up are needed. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2014-08 /pmc/articles/PMC4129561/ /pubmed/25141113 http://dx.doi.org/10.6061/clinics/2014(08)07 Text en Copyright © 2014 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Science Küçükazman, Metin Ata, Naim Dal, Kürşat Yeniova, Abdullah Özgür Kefeli, Ayşe Basyigit, Sebahat Aktas, Bora Akin, Kadir Okhan Ağladioğlu, Kadir Üre, Öznur Sari Topal, Firdes Nazligül, Yaşar Beyan, Esin Ertugrul, Derun Taner The association of vitamin D deficiency with non-alcoholic fatty liver disease |
title | The association of vitamin D deficiency with non-alcoholic fatty liver disease |
title_full | The association of vitamin D deficiency with non-alcoholic fatty liver disease |
title_fullStr | The association of vitamin D deficiency with non-alcoholic fatty liver disease |
title_full_unstemmed | The association of vitamin D deficiency with non-alcoholic fatty liver disease |
title_short | The association of vitamin D deficiency with non-alcoholic fatty liver disease |
title_sort | association of vitamin d deficiency with non-alcoholic fatty liver disease |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129561/ https://www.ncbi.nlm.nih.gov/pubmed/25141113 http://dx.doi.org/10.6061/clinics/2014(08)07 |
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