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Evolution and physiology of neural oxygen sensing

Major evolutionary trends in animal physiology have been heavily influenced by atmospheric O(2) levels. Amongst other important factors, the increase in atmospheric O(2) which occurred in the Pre-Cambrian and the development of aerobic respiration beckoned the evolution of animal organ systems that...

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Autores principales: Costa, Kauê M., Accorsi-Mendonça, Daniela, Moraes, Davi J. A., Machado, Benedito H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129633/
https://www.ncbi.nlm.nih.gov/pubmed/25161625
http://dx.doi.org/10.3389/fphys.2014.00302
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author Costa, Kauê M.
Accorsi-Mendonça, Daniela
Moraes, Davi J. A.
Machado, Benedito H.
author_facet Costa, Kauê M.
Accorsi-Mendonça, Daniela
Moraes, Davi J. A.
Machado, Benedito H.
author_sort Costa, Kauê M.
collection PubMed
description Major evolutionary trends in animal physiology have been heavily influenced by atmospheric O(2) levels. Amongst other important factors, the increase in atmospheric O(2) which occurred in the Pre-Cambrian and the development of aerobic respiration beckoned the evolution of animal organ systems that were dedicated to the absorption and transportation of O(2), e.g., the respiratory and cardiovascular systems of vertebrates. Global variations of O(2) levels in post-Cambrian periods have also been correlated with evolutionary changes in animal physiology, especially cardiorespiratory function. Oxygen transportation systems are, in our view, ultimately controlled by the brain related mechanisms, which senses changes in O(2) availability and regulates autonomic and respiratory responses that ensure the survival of the organism in the face of hypoxic challenges. In vertebrates, the major sensorial system for oxygen sensing and responding to hypoxia is the peripheral chemoreflex neuronal pathways, which includes the oxygen chemosensitive glomus cells and several brainstem regions involved in the autonomic regulation of the cardiovascular system and respiratory control. In this review we discuss the concept that regulating O(2) homeostasis was one of the primordial roles of the nervous system. We also review the physiology of the peripheral chemoreflex, focusing on the integrative repercussions of chemoreflex activation and the evolutionary importance of this system, which is essential for the survival of complex organisms such as vertebrates. The contribution of hypoxia and peripheral chemoreflex for the development of diseases associated to the cardiovascular and respiratory systems is also discussed in an evolutionary context.
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spelling pubmed-41296332014-08-26 Evolution and physiology of neural oxygen sensing Costa, Kauê M. Accorsi-Mendonça, Daniela Moraes, Davi J. A. Machado, Benedito H. Front Physiol Physiology Major evolutionary trends in animal physiology have been heavily influenced by atmospheric O(2) levels. Amongst other important factors, the increase in atmospheric O(2) which occurred in the Pre-Cambrian and the development of aerobic respiration beckoned the evolution of animal organ systems that were dedicated to the absorption and transportation of O(2), e.g., the respiratory and cardiovascular systems of vertebrates. Global variations of O(2) levels in post-Cambrian periods have also been correlated with evolutionary changes in animal physiology, especially cardiorespiratory function. Oxygen transportation systems are, in our view, ultimately controlled by the brain related mechanisms, which senses changes in O(2) availability and regulates autonomic and respiratory responses that ensure the survival of the organism in the face of hypoxic challenges. In vertebrates, the major sensorial system for oxygen sensing and responding to hypoxia is the peripheral chemoreflex neuronal pathways, which includes the oxygen chemosensitive glomus cells and several brainstem regions involved in the autonomic regulation of the cardiovascular system and respiratory control. In this review we discuss the concept that regulating O(2) homeostasis was one of the primordial roles of the nervous system. We also review the physiology of the peripheral chemoreflex, focusing on the integrative repercussions of chemoreflex activation and the evolutionary importance of this system, which is essential for the survival of complex organisms such as vertebrates. The contribution of hypoxia and peripheral chemoreflex for the development of diseases associated to the cardiovascular and respiratory systems is also discussed in an evolutionary context. Frontiers Media S.A. 2014-08-12 /pmc/articles/PMC4129633/ /pubmed/25161625 http://dx.doi.org/10.3389/fphys.2014.00302 Text en Copyright © 2014 Costa, Accorsi-Mendonça, Moraes and Machado. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Costa, Kauê M.
Accorsi-Mendonça, Daniela
Moraes, Davi J. A.
Machado, Benedito H.
Evolution and physiology of neural oxygen sensing
title Evolution and physiology of neural oxygen sensing
title_full Evolution and physiology of neural oxygen sensing
title_fullStr Evolution and physiology of neural oxygen sensing
title_full_unstemmed Evolution and physiology of neural oxygen sensing
title_short Evolution and physiology of neural oxygen sensing
title_sort evolution and physiology of neural oxygen sensing
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129633/
https://www.ncbi.nlm.nih.gov/pubmed/25161625
http://dx.doi.org/10.3389/fphys.2014.00302
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