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Leptin Effects on the Regenerative Capacity of Human Periodontal Cells
Obesity is increasing throughout the globe and characterized by excess adipose tissue, which represents a complex endocrine organ. Adipose tissue secrets bioactive molecules called adipokines, which act at endocrine, paracrine, and autocrine levels. Obesity has recently been shown to be associated w...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129942/ https://www.ncbi.nlm.nih.gov/pubmed/25136363 http://dx.doi.org/10.1155/2014/180304 |
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author | Nokhbehsaim, Marjan Keser, Sema Nogueira, Andressa Vilas Boas Jäger, Andreas Jepsen, Søren Cirelli, Joni Augusto Bourauel, Christoph Eick, Sigrun Deschner, James |
author_facet | Nokhbehsaim, Marjan Keser, Sema Nogueira, Andressa Vilas Boas Jäger, Andreas Jepsen, Søren Cirelli, Joni Augusto Bourauel, Christoph Eick, Sigrun Deschner, James |
author_sort | Nokhbehsaim, Marjan |
collection | PubMed |
description | Obesity is increasing throughout the globe and characterized by excess adipose tissue, which represents a complex endocrine organ. Adipose tissue secrets bioactive molecules called adipokines, which act at endocrine, paracrine, and autocrine levels. Obesity has recently been shown to be associated with periodontitis, a disease characterized by the irreversible destruction of the tooth-supporting tissues, that is, periodontium, and also with compromised periodontal healing. Although the underlying mechanisms for these associations are not clear yet, increased levels of proinflammatory adipokines, such as leptin, as found in obese individuals, might be a critical pathomechanistic link. The objective of this study was to examine the impact of leptin on the regenerative capacity of human periodontal ligament (PDL) cells and also to study the local leptin production by these cells. Leptin caused a significant downregulation of growth (TGFβ1, and VEGFA) and transcription (RUNX2) factors as well as matrix molecules (collagen, and periostin) and inhibited SMAD signaling under regenerative conditions. Moreover, the local expression of leptin and its full-length receptor was significantly downregulated by inflammatory, microbial, and biomechanical signals. This study demonstrates that the hormone leptin negatively interferes with the regenerative capacity of PDL cells, suggesting leptin as a pathomechanistic link between obesity and compromised periodontal healing. |
format | Online Article Text |
id | pubmed-4129942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41299422014-08-18 Leptin Effects on the Regenerative Capacity of Human Periodontal Cells Nokhbehsaim, Marjan Keser, Sema Nogueira, Andressa Vilas Boas Jäger, Andreas Jepsen, Søren Cirelli, Joni Augusto Bourauel, Christoph Eick, Sigrun Deschner, James Int J Endocrinol Research Article Obesity is increasing throughout the globe and characterized by excess adipose tissue, which represents a complex endocrine organ. Adipose tissue secrets bioactive molecules called adipokines, which act at endocrine, paracrine, and autocrine levels. Obesity has recently been shown to be associated with periodontitis, a disease characterized by the irreversible destruction of the tooth-supporting tissues, that is, periodontium, and also with compromised periodontal healing. Although the underlying mechanisms for these associations are not clear yet, increased levels of proinflammatory adipokines, such as leptin, as found in obese individuals, might be a critical pathomechanistic link. The objective of this study was to examine the impact of leptin on the regenerative capacity of human periodontal ligament (PDL) cells and also to study the local leptin production by these cells. Leptin caused a significant downregulation of growth (TGFβ1, and VEGFA) and transcription (RUNX2) factors as well as matrix molecules (collagen, and periostin) and inhibited SMAD signaling under regenerative conditions. Moreover, the local expression of leptin and its full-length receptor was significantly downregulated by inflammatory, microbial, and biomechanical signals. This study demonstrates that the hormone leptin negatively interferes with the regenerative capacity of PDL cells, suggesting leptin as a pathomechanistic link between obesity and compromised periodontal healing. Hindawi Publishing Corporation 2014 2014-07-22 /pmc/articles/PMC4129942/ /pubmed/25136363 http://dx.doi.org/10.1155/2014/180304 Text en Copyright © 2014 Marjan Nokhbehsaim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Nokhbehsaim, Marjan Keser, Sema Nogueira, Andressa Vilas Boas Jäger, Andreas Jepsen, Søren Cirelli, Joni Augusto Bourauel, Christoph Eick, Sigrun Deschner, James Leptin Effects on the Regenerative Capacity of Human Periodontal Cells |
title | Leptin Effects on the Regenerative Capacity of Human Periodontal Cells |
title_full | Leptin Effects on the Regenerative Capacity of Human Periodontal Cells |
title_fullStr | Leptin Effects on the Regenerative Capacity of Human Periodontal Cells |
title_full_unstemmed | Leptin Effects on the Regenerative Capacity of Human Periodontal Cells |
title_short | Leptin Effects on the Regenerative Capacity of Human Periodontal Cells |
title_sort | leptin effects on the regenerative capacity of human periodontal cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129942/ https://www.ncbi.nlm.nih.gov/pubmed/25136363 http://dx.doi.org/10.1155/2014/180304 |
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