BRCA-Associated Ovarian Cancer: From Molecular Genetics to Risk Management

Ovarian cancer (OC) mostly arises sporadically, but a fraction of cases are associated with mutations in BRCA1 and BRCA2 genes. The presence of a BRCA mutation in OC patients has been suggested as a prognostic and predictive factor. In addition, the identification of asymptomatic carriers of such mu...

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Autores principales: Girolimetti, Giulia, Perrone, Anna Myriam, Santini, Donatella, Barbieri, Elena, Guerra, Flora, Ferrari, Simona, Zamagni, Claudio, De Iaco, Pierandrea, Gasparre, Giuseppe, Turchetti, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129974/
https://www.ncbi.nlm.nih.gov/pubmed/25136623
http://dx.doi.org/10.1155/2014/787143
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author Girolimetti, Giulia
Perrone, Anna Myriam
Santini, Donatella
Barbieri, Elena
Guerra, Flora
Ferrari, Simona
Zamagni, Claudio
De Iaco, Pierandrea
Gasparre, Giuseppe
Turchetti, Daniela
author_facet Girolimetti, Giulia
Perrone, Anna Myriam
Santini, Donatella
Barbieri, Elena
Guerra, Flora
Ferrari, Simona
Zamagni, Claudio
De Iaco, Pierandrea
Gasparre, Giuseppe
Turchetti, Daniela
author_sort Girolimetti, Giulia
collection PubMed
description Ovarian cancer (OC) mostly arises sporadically, but a fraction of cases are associated with mutations in BRCA1 and BRCA2 genes. The presence of a BRCA mutation in OC patients has been suggested as a prognostic and predictive factor. In addition, the identification of asymptomatic carriers of such mutations offers an unprecedented opportunity for OC prevention. This review is aimed at exploring the current knowledge on epidemiological and molecular aspects of BRCA-associated OC predisposition, on pathology and clinical behavior of OC occurring in BRCA mutation carriers, and on the available options for managing asymptomatic carriers.
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spelling pubmed-41299742014-08-18 BRCA-Associated Ovarian Cancer: From Molecular Genetics to Risk Management Girolimetti, Giulia Perrone, Anna Myriam Santini, Donatella Barbieri, Elena Guerra, Flora Ferrari, Simona Zamagni, Claudio De Iaco, Pierandrea Gasparre, Giuseppe Turchetti, Daniela Biomed Res Int Review Article Ovarian cancer (OC) mostly arises sporadically, but a fraction of cases are associated with mutations in BRCA1 and BRCA2 genes. The presence of a BRCA mutation in OC patients has been suggested as a prognostic and predictive factor. In addition, the identification of asymptomatic carriers of such mutations offers an unprecedented opportunity for OC prevention. This review is aimed at exploring the current knowledge on epidemiological and molecular aspects of BRCA-associated OC predisposition, on pathology and clinical behavior of OC occurring in BRCA mutation carriers, and on the available options for managing asymptomatic carriers. Hindawi Publishing Corporation 2014 2014-07-22 /pmc/articles/PMC4129974/ /pubmed/25136623 http://dx.doi.org/10.1155/2014/787143 Text en Copyright © 2014 Giulia Girolimetti et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Girolimetti, Giulia
Perrone, Anna Myriam
Santini, Donatella
Barbieri, Elena
Guerra, Flora
Ferrari, Simona
Zamagni, Claudio
De Iaco, Pierandrea
Gasparre, Giuseppe
Turchetti, Daniela
BRCA-Associated Ovarian Cancer: From Molecular Genetics to Risk Management
title BRCA-Associated Ovarian Cancer: From Molecular Genetics to Risk Management
title_full BRCA-Associated Ovarian Cancer: From Molecular Genetics to Risk Management
title_fullStr BRCA-Associated Ovarian Cancer: From Molecular Genetics to Risk Management
title_full_unstemmed BRCA-Associated Ovarian Cancer: From Molecular Genetics to Risk Management
title_short BRCA-Associated Ovarian Cancer: From Molecular Genetics to Risk Management
title_sort brca-associated ovarian cancer: from molecular genetics to risk management
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129974/
https://www.ncbi.nlm.nih.gov/pubmed/25136623
http://dx.doi.org/10.1155/2014/787143
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