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Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control
Apoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell stress, injury, and chemotherapeutics exposure. Dying and death cells release a variety of self-proteins and bioactive chemicals originated from...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130149/ https://www.ncbi.nlm.nih.gov/pubmed/25140116 http://dx.doi.org/10.1155/2014/821043 |
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author | Sangiuliano, Beatriz Pérez, Nancy Marcela Moreira, Dayson F. Belizário, José E. |
author_facet | Sangiuliano, Beatriz Pérez, Nancy Marcela Moreira, Dayson F. Belizário, José E. |
author_sort | Sangiuliano, Beatriz |
collection | PubMed |
description | Apoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell stress, injury, and chemotherapeutics exposure. Dying and death cells release a variety of self-proteins and bioactive chemicals originated from cytosol, nucleus, endoplasmic reticulum, and mitochondria. These endogenous factors are named cell death-associated molecular-pattern (CDAMP), damage-associated molecular-pattern (DAMP) molecules, and alarmins. Some of them cooperate or act as important initial or delayed inflammatory mediators upon binding to diverse membrane and cytosolic receptors coupled to signaling pathways for the activation of the inflammasome platforms and NF-κB multiprotein complexes. Current studies show that the nonprotein thiols and thiol-regulating enzymes as well as highly diffusible prooxidant reactive oxygen and nitrogen species released together in extracellular inflammatory milieu play essential role in controlling pro- and anti-inflammatory activities of CDAMP/DAMP and alarmins. Here, we provide an overview of these emerging concepts and mechanisms of triggering and maintenance of tissue inflammation under massive death of cells. |
format | Online Article Text |
id | pubmed-4130149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41301492014-08-19 Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control Sangiuliano, Beatriz Pérez, Nancy Marcela Moreira, Dayson F. Belizário, José E. Mediators Inflamm Review Article Apoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell stress, injury, and chemotherapeutics exposure. Dying and death cells release a variety of self-proteins and bioactive chemicals originated from cytosol, nucleus, endoplasmic reticulum, and mitochondria. These endogenous factors are named cell death-associated molecular-pattern (CDAMP), damage-associated molecular-pattern (DAMP) molecules, and alarmins. Some of them cooperate or act as important initial or delayed inflammatory mediators upon binding to diverse membrane and cytosolic receptors coupled to signaling pathways for the activation of the inflammasome platforms and NF-κB multiprotein complexes. Current studies show that the nonprotein thiols and thiol-regulating enzymes as well as highly diffusible prooxidant reactive oxygen and nitrogen species released together in extracellular inflammatory milieu play essential role in controlling pro- and anti-inflammatory activities of CDAMP/DAMP and alarmins. Here, we provide an overview of these emerging concepts and mechanisms of triggering and maintenance of tissue inflammation under massive death of cells. Hindawi Publishing Corporation 2014 2014-07-21 /pmc/articles/PMC4130149/ /pubmed/25140116 http://dx.doi.org/10.1155/2014/821043 Text en Copyright © 2014 Beatriz Sangiuliano et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sangiuliano, Beatriz Pérez, Nancy Marcela Moreira, Dayson F. Belizário, José E. Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control |
title | Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control |
title_full | Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control |
title_fullStr | Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control |
title_full_unstemmed | Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control |
title_short | Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control |
title_sort | cell death-associated molecular-pattern molecules: inflammatory signaling and control |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130149/ https://www.ncbi.nlm.nih.gov/pubmed/25140116 http://dx.doi.org/10.1155/2014/821043 |
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