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Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control

Apoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell stress, injury, and chemotherapeutics exposure. Dying and death cells release a variety of self-proteins and bioactive chemicals originated from...

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Autores principales: Sangiuliano, Beatriz, Pérez, Nancy Marcela, Moreira, Dayson F., Belizário, José E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130149/
https://www.ncbi.nlm.nih.gov/pubmed/25140116
http://dx.doi.org/10.1155/2014/821043
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author Sangiuliano, Beatriz
Pérez, Nancy Marcela
Moreira, Dayson F.
Belizário, José E.
author_facet Sangiuliano, Beatriz
Pérez, Nancy Marcela
Moreira, Dayson F.
Belizário, José E.
author_sort Sangiuliano, Beatriz
collection PubMed
description Apoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell stress, injury, and chemotherapeutics exposure. Dying and death cells release a variety of self-proteins and bioactive chemicals originated from cytosol, nucleus, endoplasmic reticulum, and mitochondria. These endogenous factors are named cell death-associated molecular-pattern (CDAMP), damage-associated molecular-pattern (DAMP) molecules, and alarmins. Some of them cooperate or act as important initial or delayed inflammatory mediators upon binding to diverse membrane and cytosolic receptors coupled to signaling pathways for the activation of the inflammasome platforms and NF-κB multiprotein complexes. Current studies show that the nonprotein thiols and thiol-regulating enzymes as well as highly diffusible prooxidant reactive oxygen and nitrogen species released together in extracellular inflammatory milieu play essential role in controlling pro- and anti-inflammatory activities of CDAMP/DAMP and alarmins. Here, we provide an overview of these emerging concepts and mechanisms of triggering and maintenance of tissue inflammation under massive death of cells.
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spelling pubmed-41301492014-08-19 Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control Sangiuliano, Beatriz Pérez, Nancy Marcela Moreira, Dayson F. Belizário, José E. Mediators Inflamm Review Article Apoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell stress, injury, and chemotherapeutics exposure. Dying and death cells release a variety of self-proteins and bioactive chemicals originated from cytosol, nucleus, endoplasmic reticulum, and mitochondria. These endogenous factors are named cell death-associated molecular-pattern (CDAMP), damage-associated molecular-pattern (DAMP) molecules, and alarmins. Some of them cooperate or act as important initial or delayed inflammatory mediators upon binding to diverse membrane and cytosolic receptors coupled to signaling pathways for the activation of the inflammasome platforms and NF-κB multiprotein complexes. Current studies show that the nonprotein thiols and thiol-regulating enzymes as well as highly diffusible prooxidant reactive oxygen and nitrogen species released together in extracellular inflammatory milieu play essential role in controlling pro- and anti-inflammatory activities of CDAMP/DAMP and alarmins. Here, we provide an overview of these emerging concepts and mechanisms of triggering and maintenance of tissue inflammation under massive death of cells. Hindawi Publishing Corporation 2014 2014-07-21 /pmc/articles/PMC4130149/ /pubmed/25140116 http://dx.doi.org/10.1155/2014/821043 Text en Copyright © 2014 Beatriz Sangiuliano et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sangiuliano, Beatriz
Pérez, Nancy Marcela
Moreira, Dayson F.
Belizário, José E.
Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control
title Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control
title_full Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control
title_fullStr Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control
title_full_unstemmed Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control
title_short Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control
title_sort cell death-associated molecular-pattern molecules: inflammatory signaling and control
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130149/
https://www.ncbi.nlm.nih.gov/pubmed/25140116
http://dx.doi.org/10.1155/2014/821043
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