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On the Coupling of Two Models of the Human Immune Response to an Antigen

The development of mathematical models of the immune response allows a better understanding of the multifaceted mechanisms of the defense system. The main purpose of this work is to present a scheme for coupling distinct models of different scales and aspects of the immune system. As an example, we...

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Detalles Bibliográficos
Autores principales: Quintela, Bárbara de M., dos Santos, Rodrigo Weber, Lobosco, Marcelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130187/
https://www.ncbi.nlm.nih.gov/pubmed/25140313
http://dx.doi.org/10.1155/2014/410457
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author Quintela, Bárbara de M.
dos Santos, Rodrigo Weber
Lobosco, Marcelo
author_facet Quintela, Bárbara de M.
dos Santos, Rodrigo Weber
Lobosco, Marcelo
author_sort Quintela, Bárbara de M.
collection PubMed
description The development of mathematical models of the immune response allows a better understanding of the multifaceted mechanisms of the defense system. The main purpose of this work is to present a scheme for coupling distinct models of different scales and aspects of the immune system. As an example, we propose a new model where the local tissue inflammation processes are simulated with partial differential equations (PDEs) whereas a system of ordinary differential equations (ODEs) is used as a model for the systemic response. The simulation of distinct scenarios allows the analysis of the dynamics of various immune cells in the presence of an antigen. Preliminary results of this approach with a sensitivity analysis of the coupled model are shown but further validation is still required.
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spelling pubmed-41301872014-08-19 On the Coupling of Two Models of the Human Immune Response to an Antigen Quintela, Bárbara de M. dos Santos, Rodrigo Weber Lobosco, Marcelo Biomed Res Int Research Article The development of mathematical models of the immune response allows a better understanding of the multifaceted mechanisms of the defense system. The main purpose of this work is to present a scheme for coupling distinct models of different scales and aspects of the immune system. As an example, we propose a new model where the local tissue inflammation processes are simulated with partial differential equations (PDEs) whereas a system of ordinary differential equations (ODEs) is used as a model for the systemic response. The simulation of distinct scenarios allows the analysis of the dynamics of various immune cells in the presence of an antigen. Preliminary results of this approach with a sensitivity analysis of the coupled model are shown but further validation is still required. Hindawi Publishing Corporation 2014 2014-07-22 /pmc/articles/PMC4130187/ /pubmed/25140313 http://dx.doi.org/10.1155/2014/410457 Text en Copyright © 2014 Bárbara de M. Quintela et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Quintela, Bárbara de M.
dos Santos, Rodrigo Weber
Lobosco, Marcelo
On the Coupling of Two Models of the Human Immune Response to an Antigen
title On the Coupling of Two Models of the Human Immune Response to an Antigen
title_full On the Coupling of Two Models of the Human Immune Response to an Antigen
title_fullStr On the Coupling of Two Models of the Human Immune Response to an Antigen
title_full_unstemmed On the Coupling of Two Models of the Human Immune Response to an Antigen
title_short On the Coupling of Two Models of the Human Immune Response to an Antigen
title_sort on the coupling of two models of the human immune response to an antigen
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130187/
https://www.ncbi.nlm.nih.gov/pubmed/25140313
http://dx.doi.org/10.1155/2014/410457
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