Fragment-Based Library Generation for the Discovery of a Peptidomimetic p53-Mdm4 Inhibitor

[Image: see text] On the basis of our recently resolved first cocrystal structure of Mdm4 in complex with a small molecule inhibitor (PDB ID 3LBJ), we devised an approach for the generation of potential Mdm4 selective ligands. We performed the Ugi four-component reaction (Ugi-4CR) in 96-well plates...

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Detalles Bibliográficos
Autores principales: Boltjes, André, Huang, Yijun, van de Velde, Rob, Rijkee, Laurie, Wolf, Siglinde, Gaugler, James, Lesniak, Katarzyna, Guzik, Katarzyna, Holak, Tad A., Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130243/
https://www.ncbi.nlm.nih.gov/pubmed/24983416
http://dx.doi.org/10.1021/co500026b

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