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Etiology of Severe Childhood Pneumonia in The Gambia, West Africa, Determined by Conventional and Molecular Microbiological Analyses of Lung and Pleural Aspirate Samples
Molecular analyses of lung aspirates from Gambian children with severe pneumonia detected pathogens more frequently than did culture and showed a predominance of bacteria, principally Streptococcuspneumoniae, >75% being of serotypes covered by current pneumococcal conjugate vaccines. Multiple pat...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130311/ https://www.ncbi.nlm.nih.gov/pubmed/24867789 http://dx.doi.org/10.1093/cid/ciu384 |
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| author | Howie, Stephen R. C. Morris, Gerard A. J. Tokarz, Rafal Ebruke, Bernard E. Machuka, Eunice M. Ideh, Readon C. Chimah, Osaretin Secka, Ousman Townend, John Dione, Michel Oluwalana, Claire Njie, Malick Jallow, Mariatou Hill, Philip C. Antonio, Martin Greenwood, Brian Briese, Thomas Mulholland, Kim Corrah, Tumani Lipkin, W. Ian Adegbola, Richard A. |
| author_facet | Howie, Stephen R. C. Morris, Gerard A. J. Tokarz, Rafal Ebruke, Bernard E. Machuka, Eunice M. Ideh, Readon C. Chimah, Osaretin Secka, Ousman Townend, John Dione, Michel Oluwalana, Claire Njie, Malick Jallow, Mariatou Hill, Philip C. Antonio, Martin Greenwood, Brian Briese, Thomas Mulholland, Kim Corrah, Tumani Lipkin, W. Ian Adegbola, Richard A. |
| author_sort | Howie, Stephen R. C. |
| collection | PubMed |
| description | Molecular analyses of lung aspirates from Gambian children with severe pneumonia detected pathogens more frequently than did culture and showed a predominance of bacteria, principally Streptococcuspneumoniae, >75% being of serotypes covered by current pneumococcal conjugate vaccines. Multiple pathogens were detected frequently, notably Haemophilus influenzae (mostly nontypeable) together with S. pneumoniae. |
| format | Online Article Text |
| id | pubmed-4130311 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-41303112014-08-15 Etiology of Severe Childhood Pneumonia in The Gambia, West Africa, Determined by Conventional and Molecular Microbiological Analyses of Lung and Pleural Aspirate Samples Howie, Stephen R. C. Morris, Gerard A. J. Tokarz, Rafal Ebruke, Bernard E. Machuka, Eunice M. Ideh, Readon C. Chimah, Osaretin Secka, Ousman Townend, John Dione, Michel Oluwalana, Claire Njie, Malick Jallow, Mariatou Hill, Philip C. Antonio, Martin Greenwood, Brian Briese, Thomas Mulholland, Kim Corrah, Tumani Lipkin, W. Ian Adegbola, Richard A. Clin Infect Dis Brief Report Molecular analyses of lung aspirates from Gambian children with severe pneumonia detected pathogens more frequently than did culture and showed a predominance of bacteria, principally Streptococcuspneumoniae, >75% being of serotypes covered by current pneumococcal conjugate vaccines. Multiple pathogens were detected frequently, notably Haemophilus influenzae (mostly nontypeable) together with S. pneumoniae. Oxford University Press 2014-09-01 2014-05-27 /pmc/articles/PMC4130311/ /pubmed/24867789 http://dx.doi.org/10.1093/cid/ciu384 Text en © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
| spellingShingle | Brief Report Howie, Stephen R. C. Morris, Gerard A. J. Tokarz, Rafal Ebruke, Bernard E. Machuka, Eunice M. Ideh, Readon C. Chimah, Osaretin Secka, Ousman Townend, John Dione, Michel Oluwalana, Claire Njie, Malick Jallow, Mariatou Hill, Philip C. Antonio, Martin Greenwood, Brian Briese, Thomas Mulholland, Kim Corrah, Tumani Lipkin, W. Ian Adegbola, Richard A. Etiology of Severe Childhood Pneumonia in The Gambia, West Africa, Determined by Conventional and Molecular Microbiological Analyses of Lung and Pleural Aspirate Samples |
| title | Etiology of Severe Childhood Pneumonia in The Gambia, West Africa, Determined by Conventional and Molecular Microbiological Analyses of Lung and Pleural Aspirate Samples |
| title_full | Etiology of Severe Childhood Pneumonia in The Gambia, West Africa, Determined by Conventional and Molecular Microbiological Analyses of Lung and Pleural Aspirate Samples |
| title_fullStr | Etiology of Severe Childhood Pneumonia in The Gambia, West Africa, Determined by Conventional and Molecular Microbiological Analyses of Lung and Pleural Aspirate Samples |
| title_full_unstemmed | Etiology of Severe Childhood Pneumonia in The Gambia, West Africa, Determined by Conventional and Molecular Microbiological Analyses of Lung and Pleural Aspirate Samples |
| title_short | Etiology of Severe Childhood Pneumonia in The Gambia, West Africa, Determined by Conventional and Molecular Microbiological Analyses of Lung and Pleural Aspirate Samples |
| title_sort | etiology of severe childhood pneumonia in the gambia, west africa, determined by conventional and molecular microbiological analyses of lung and pleural aspirate samples |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130311/ https://www.ncbi.nlm.nih.gov/pubmed/24867789 http://dx.doi.org/10.1093/cid/ciu384 |
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