Decitabine and SAHA-Induced Apoptosis Is Accompanied by Survivin Downregulation and Potentiated by ATRA in p53-Deficient Cells

While p53-dependent apoptosis is triggered by combination of methyltransferase inhibitor decitabine (DAC) and histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) in leukemic cell line CML-T1, reactive oxygen species (ROS) generation as well as survivin and Bcl-2 deregulation partici...

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Detalles Bibliográficos
Autores principales: Brodská, Barbora, Otevřelová, Petra, Holoubek, Aleš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130322/
https://www.ncbi.nlm.nih.gov/pubmed/25140197
http://dx.doi.org/10.1155/2014/165303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130322/
https://www.ncbi.nlm.nih.gov/pubmed/25140197
http://dx.doi.org/10.1155/2014/165303

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