New strategy to control cell migration and metastasis regulated by CCN2/CTGF

Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epit...

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Autores principales: Aguiar, Diego Pinheiro, de Farias, Gabriel Correa, de Sousa, Eduardo Branco, de Mattos Coelho-Aguiar, Juliana, Lobo, Julie Calixto, Casado, Priscila Ladeira, Duarte, Maria Eugênia Leite, Abreu, José Garcia Ribeiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130434/
https://www.ncbi.nlm.nih.gov/pubmed/25120383
http://dx.doi.org/10.1186/1475-2867-14-61
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author Aguiar, Diego Pinheiro
de Farias, Gabriel Correa
de Sousa, Eduardo Branco
de Mattos Coelho-Aguiar, Juliana
Lobo, Julie Calixto
Casado, Priscila Ladeira
Duarte, Maria Eugênia Leite
Abreu, José Garcia Ribeiro
author_facet Aguiar, Diego Pinheiro
de Farias, Gabriel Correa
de Sousa, Eduardo Branco
de Mattos Coelho-Aguiar, Juliana
Lobo, Julie Calixto
Casado, Priscila Ladeira
Duarte, Maria Eugênia Leite
Abreu, José Garcia Ribeiro
author_sort Aguiar, Diego Pinheiro
collection PubMed
description Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth muscle and also pluripotent stem cells. Others matricellular proteins are capable of interacting with CCN2/CTGF to mediate its function. Cell migration is a key feature for tumor cell invasion and metastasis. CCN2/CTGF seems to be a prognostic marker for cancer. In addition, here we intend to discuss recent discoveries and a new strategy to develop therapies against CCN2/CTGF, in order to treat cancer metastasis.
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spelling pubmed-41304342014-08-13 New strategy to control cell migration and metastasis regulated by CCN2/CTGF Aguiar, Diego Pinheiro de Farias, Gabriel Correa de Sousa, Eduardo Branco de Mattos Coelho-Aguiar, Juliana Lobo, Julie Calixto Casado, Priscila Ladeira Duarte, Maria Eugênia Leite Abreu, José Garcia Ribeiro Cancer Cell Int Review Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth muscle and also pluripotent stem cells. Others matricellular proteins are capable of interacting with CCN2/CTGF to mediate its function. Cell migration is a key feature for tumor cell invasion and metastasis. CCN2/CTGF seems to be a prognostic marker for cancer. In addition, here we intend to discuss recent discoveries and a new strategy to develop therapies against CCN2/CTGF, in order to treat cancer metastasis. BioMed Central 2014-07-12 /pmc/articles/PMC4130434/ /pubmed/25120383 http://dx.doi.org/10.1186/1475-2867-14-61 Text en Copyright © 2014 Aguiar et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Aguiar, Diego Pinheiro
de Farias, Gabriel Correa
de Sousa, Eduardo Branco
de Mattos Coelho-Aguiar, Juliana
Lobo, Julie Calixto
Casado, Priscila Ladeira
Duarte, Maria Eugênia Leite
Abreu, José Garcia Ribeiro
New strategy to control cell migration and metastasis regulated by CCN2/CTGF
title New strategy to control cell migration and metastasis regulated by CCN2/CTGF
title_full New strategy to control cell migration and metastasis regulated by CCN2/CTGF
title_fullStr New strategy to control cell migration and metastasis regulated by CCN2/CTGF
title_full_unstemmed New strategy to control cell migration and metastasis regulated by CCN2/CTGF
title_short New strategy to control cell migration and metastasis regulated by CCN2/CTGF
title_sort new strategy to control cell migration and metastasis regulated by ccn2/ctgf
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130434/
https://www.ncbi.nlm.nih.gov/pubmed/25120383
http://dx.doi.org/10.1186/1475-2867-14-61
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