An Airway Epithelial iNOS-DUOX2-Thyroid Peroxidase Metabolome Drives Th1/Th2 Nitrative Stress in Human Severe Asthma

Severe refractory asthma is associated with enhanced nitrative stress. To determine the mechanisms for high nitrative stress in human severe asthma, 3-nitrotyrosine (3NT) was compared with Th1 and Th2 cytokine expression. In severe asthma, high 3NT levels were associated with high IFN-γ and low IL-1...

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Detalles Bibliográficos
Autores principales: Voraphani, N, Gladwin, MT, Contreras, AU, Kaminski, N, Tedrow, JR, Milosevic, J, Bleecker, ER, Meyers, DA, Ray, A, Ray, P, Erzurum, SC, Busse, WW, Zhao, J, Trudeau, JB, Wenzel, SE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130801/
https://www.ncbi.nlm.nih.gov/pubmed/24518246
http://dx.doi.org/10.1038/mi.2014.6

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