3'-Ethynylcytidine, an RNA polymerase inhibitor, combined with cisplatin exhibits a potent synergistic growth-inhibitory effect via Vaults dysfunction

BACKGROUND: We previously reported that 3'-ethynylcytidine (ECyd, TAS-106), an RNA polymerases inhibitor, enhances the anti-tumor efficacy of platinum in several tumor types in both in vitro and in vivo tumor models. However, the molecular mechanisms underlying the ECyd-induced enhancement rema...

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Detalles Bibliográficos
Autores principales: Fukushima, Hiroto, Abe, Tetsuya, Sakamoto, Kazuki, Tsujimoto, Hiroaki, Mizuarai, Shinji, Oie, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131025/
https://www.ncbi.nlm.nih.gov/pubmed/25087851
http://dx.doi.org/10.1186/1471-2407-14-562

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