HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy

HLA-G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or allograft transplantation, the expression of HLA-G has been related to a better acceptance of the fetus or the allograft. Thus, it seems that HLA-G is crucially involved in mechanisms shaping an allogeneic im...

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Detalles Bibliográficos
Autores principales: Rebmann, Vera, da Silva Nardi, Fabiola, Wagner, Bettina, Horn, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131093/
https://www.ncbi.nlm.nih.gov/pubmed/25143957
http://dx.doi.org/10.1155/2014/297073
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author Rebmann, Vera
da Silva Nardi, Fabiola
Wagner, Bettina
Horn, Peter A.
author_facet Rebmann, Vera
da Silva Nardi, Fabiola
Wagner, Bettina
Horn, Peter A.
author_sort Rebmann, Vera
collection PubMed
description HLA-G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or allograft transplantation, the expression of HLA-G has been related to a better acceptance of the fetus or the allograft. Thus, it seems that HLA-G is crucially involved in mechanisms shaping an allogeneic immune response into tolerance. In this contribution we focus on (i) how HLA-G is involved in transplantation and human reproduction, (ii) how HLA-G is regulated by genetic and microenvironmental factors, and (iii) how HLA-G can offer novel perspectives with respect to therapy.
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spelling pubmed-41310932014-08-20 HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy Rebmann, Vera da Silva Nardi, Fabiola Wagner, Bettina Horn, Peter A. J Immunol Res Review Article HLA-G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or allograft transplantation, the expression of HLA-G has been related to a better acceptance of the fetus or the allograft. Thus, it seems that HLA-G is crucially involved in mechanisms shaping an allogeneic immune response into tolerance. In this contribution we focus on (i) how HLA-G is involved in transplantation and human reproduction, (ii) how HLA-G is regulated by genetic and microenvironmental factors, and (iii) how HLA-G can offer novel perspectives with respect to therapy. Hindawi Publishing Corporation 2014 2014-07-21 /pmc/articles/PMC4131093/ /pubmed/25143957 http://dx.doi.org/10.1155/2014/297073 Text en Copyright © 2014 Vera Rebmann et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rebmann, Vera
da Silva Nardi, Fabiola
Wagner, Bettina
Horn, Peter A.
HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy
title HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy
title_full HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy
title_fullStr HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy
title_full_unstemmed HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy
title_short HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy
title_sort hla-g as a tolerogenic molecule in transplantation and pregnancy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131093/
https://www.ncbi.nlm.nih.gov/pubmed/25143957
http://dx.doi.org/10.1155/2014/297073
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