Bone Morbidity in Childhood Leukemia: Epidemiology, Mechanisms, Diagnosis, and Treatment

Skeletal abnormalities are commonly seen in children and adolescents with leukemia. The spectrum ranges from mild pain to debilitating osteonecrosis (ON) and fractures. In this review, we summarize the skeletal manifestations, provide an update on therapeutic strategies for prevention and treatment,...

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Autores principales: Mostoufi-Moab, Sogol, Halton, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Pediatrics (M Leonard and L Ward, Section Editors)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131149/
https://www.ncbi.nlm.nih.gov/pubmed/24986711
http://dx.doi.org/10.1007/s11914-014-0222-3
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author Mostoufi-Moab, Sogol
Halton, Jacqueline
author_facet Mostoufi-Moab, Sogol
Halton, Jacqueline
author_sort Mostoufi-Moab, Sogol
collection PubMed
description Skeletal abnormalities are commonly seen in children and adolescents with leukemia. The spectrum ranges from mild pain to debilitating osteonecrosis (ON) and fractures. In this review, we summarize the skeletal manifestations, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life observed in children and adolescents with leukemia.
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spelling pubmed-41311492014-08-14 Bone Morbidity in Childhood Leukemia: Epidemiology, Mechanisms, Diagnosis, and Treatment Mostoufi-Moab, Sogol Halton, Jacqueline Curr Osteoporos Rep Pediatrics (M Leonard and L Ward, Section Editors) Skeletal abnormalities are commonly seen in children and adolescents with leukemia. The spectrum ranges from mild pain to debilitating osteonecrosis (ON) and fractures. In this review, we summarize the skeletal manifestations, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life observed in children and adolescents with leukemia. Springer US 2014-07-02 2014 /pmc/articles/PMC4131149/ /pubmed/24986711 http://dx.doi.org/10.1007/s11914-014-0222-3 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Pediatrics (M Leonard and L Ward, Section Editors)
Mostoufi-Moab, Sogol
Halton, Jacqueline
Bone Morbidity in Childhood Leukemia: Epidemiology, Mechanisms, Diagnosis, and Treatment
title Bone Morbidity in Childhood Leukemia: Epidemiology, Mechanisms, Diagnosis, and Treatment
title_full Bone Morbidity in Childhood Leukemia: Epidemiology, Mechanisms, Diagnosis, and Treatment
title_fullStr Bone Morbidity in Childhood Leukemia: Epidemiology, Mechanisms, Diagnosis, and Treatment
title_full_unstemmed Bone Morbidity in Childhood Leukemia: Epidemiology, Mechanisms, Diagnosis, and Treatment
title_short Bone Morbidity in Childhood Leukemia: Epidemiology, Mechanisms, Diagnosis, and Treatment
title_sort bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment
topic Pediatrics (M Leonard and L Ward, Section Editors)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131149/
https://www.ncbi.nlm.nih.gov/pubmed/24986711
http://dx.doi.org/10.1007/s11914-014-0222-3
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