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Evaluation of analgesic activity of perindopril in albino mice

The aim was to evaluate the analgesic activity of perindopril in chemical, thermal and mechanical pain on Swiss albino mice. A total of 54 albino mice (Swiss strain) weighing 25-30 g were allocated to each experimental model and in each model there were three groups. The control group received norma...

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Autores principales: Suresha, R. N., Amoghimath, Siddamma, Vaibhavi, P. S., Shruthi, S. L., Jayanthi, M. K., Kalabharathi, H. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131403/
https://www.ncbi.nlm.nih.gov/pubmed/25126534
http://dx.doi.org/10.4103/2231-4040.137423
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author Suresha, R. N.
Amoghimath, Siddamma
Vaibhavi, P. S.
Shruthi, S. L.
Jayanthi, M. K.
Kalabharathi, H. L.
author_facet Suresha, R. N.
Amoghimath, Siddamma
Vaibhavi, P. S.
Shruthi, S. L.
Jayanthi, M. K.
Kalabharathi, H. L.
author_sort Suresha, R. N.
collection PubMed
description The aim was to evaluate the analgesic activity of perindopril in chemical, thermal and mechanical pain on Swiss albino mice. A total of 54 albino mice (Swiss strain) weighing 25-30 g were allocated to each experimental model and in each model there were three groups. The control group received normal saline (25 ml/kg) per orally, standard group received pentazocine (10 mg/kg) intra-peritoneal and test groups received perindopril (1 mg/kg) per orally. Perindopril and normal saline was administered 2 h before, whereas the pentazocine was administered 15 min prior to Eddy's hot plate, writhing and tail clip methods. The decrease in number of writhes, the delay in reaction time in tail clip and Eddy's hot plate method denoted the analgesic activity. Perindopril decreased the number of writhes, delayed the reaction time in tail clip and Eddy's hot plate method considerably when compared with control (normal saline), but less when compared with standard (pentazocine). Perindopril exhibits analgesic activity in thermal, chemical, and mechanical pain models in albino mice.
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spelling pubmed-41314032014-08-14 Evaluation of analgesic activity of perindopril in albino mice Suresha, R. N. Amoghimath, Siddamma Vaibhavi, P. S. Shruthi, S. L. Jayanthi, M. K. Kalabharathi, H. L. J Adv Pharm Technol Res Original Article The aim was to evaluate the analgesic activity of perindopril in chemical, thermal and mechanical pain on Swiss albino mice. A total of 54 albino mice (Swiss strain) weighing 25-30 g were allocated to each experimental model and in each model there were three groups. The control group received normal saline (25 ml/kg) per orally, standard group received pentazocine (10 mg/kg) intra-peritoneal and test groups received perindopril (1 mg/kg) per orally. Perindopril and normal saline was administered 2 h before, whereas the pentazocine was administered 15 min prior to Eddy's hot plate, writhing and tail clip methods. The decrease in number of writhes, the delay in reaction time in tail clip and Eddy's hot plate method denoted the analgesic activity. Perindopril decreased the number of writhes, delayed the reaction time in tail clip and Eddy's hot plate method considerably when compared with control (normal saline), but less when compared with standard (pentazocine). Perindopril exhibits analgesic activity in thermal, chemical, and mechanical pain models in albino mice. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4131403/ /pubmed/25126534 http://dx.doi.org/10.4103/2231-4040.137423 Text en Copyright: © Journal of Advanced Pharmaceutical Technology & Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Suresha, R. N.
Amoghimath, Siddamma
Vaibhavi, P. S.
Shruthi, S. L.
Jayanthi, M. K.
Kalabharathi, H. L.
Evaluation of analgesic activity of perindopril in albino mice
title Evaluation of analgesic activity of perindopril in albino mice
title_full Evaluation of analgesic activity of perindopril in albino mice
title_fullStr Evaluation of analgesic activity of perindopril in albino mice
title_full_unstemmed Evaluation of analgesic activity of perindopril in albino mice
title_short Evaluation of analgesic activity of perindopril in albino mice
title_sort evaluation of analgesic activity of perindopril in albino mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131403/
https://www.ncbi.nlm.nih.gov/pubmed/25126534
http://dx.doi.org/10.4103/2231-4040.137423
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