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Protective Effects of Panax Notoginseng Saponins on Cardiovascular Diseases: A Comprehensive Overview of Experimental Studies

Panax notoginseng saponins (PNS) are one of the most important compounds derived from roots of the herb Panax notoginseng which are traditionally used as a hemostatic medicine to control internal and external bleeding in China for thousands of years. To date, at least twenty saponins were identified...

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Detalles Bibliográficos
Autores principales: Yang, Xiaochen, Xiong, Xingjiang, Wang, Heran, Wang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131460/
https://www.ncbi.nlm.nih.gov/pubmed/25152758
http://dx.doi.org/10.1155/2014/204840
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author Yang, Xiaochen
Xiong, Xingjiang
Wang, Heran
Wang, Jie
author_facet Yang, Xiaochen
Xiong, Xingjiang
Wang, Heran
Wang, Jie
author_sort Yang, Xiaochen
collection PubMed
description Panax notoginseng saponins (PNS) are one of the most important compounds derived from roots of the herb Panax notoginseng which are traditionally used as a hemostatic medicine to control internal and external bleeding in China for thousands of years. To date, at least twenty saponins were identified and some of them including notoginsenoside R1, ginsenoside Rb1, and ginsenoside Rg1 were researched frequently in the area of cardiovascular protection. However, the protective effects of PNS on cardiovascular diseases based on experimental studies and its underlying mechanisms have not been reviewed systematically. This paper reviewed the pharmacology of PNS and its monomers Rb1, Rg1, and R1 in the treatment for cardiovascular diseases.
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spelling pubmed-41314602014-08-24 Protective Effects of Panax Notoginseng Saponins on Cardiovascular Diseases: A Comprehensive Overview of Experimental Studies Yang, Xiaochen Xiong, Xingjiang Wang, Heran Wang, Jie Evid Based Complement Alternat Med Review Article Panax notoginseng saponins (PNS) are one of the most important compounds derived from roots of the herb Panax notoginseng which are traditionally used as a hemostatic medicine to control internal and external bleeding in China for thousands of years. To date, at least twenty saponins were identified and some of them including notoginsenoside R1, ginsenoside Rb1, and ginsenoside Rg1 were researched frequently in the area of cardiovascular protection. However, the protective effects of PNS on cardiovascular diseases based on experimental studies and its underlying mechanisms have not been reviewed systematically. This paper reviewed the pharmacology of PNS and its monomers Rb1, Rg1, and R1 in the treatment for cardiovascular diseases. Hindawi Publishing Corporation 2014 2014-07-24 /pmc/articles/PMC4131460/ /pubmed/25152758 http://dx.doi.org/10.1155/2014/204840 Text en Copyright © 2014 Xiaochen Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yang, Xiaochen
Xiong, Xingjiang
Wang, Heran
Wang, Jie
Protective Effects of Panax Notoginseng Saponins on Cardiovascular Diseases: A Comprehensive Overview of Experimental Studies
title Protective Effects of Panax Notoginseng Saponins on Cardiovascular Diseases: A Comprehensive Overview of Experimental Studies
title_full Protective Effects of Panax Notoginseng Saponins on Cardiovascular Diseases: A Comprehensive Overview of Experimental Studies
title_fullStr Protective Effects of Panax Notoginseng Saponins on Cardiovascular Diseases: A Comprehensive Overview of Experimental Studies
title_full_unstemmed Protective Effects of Panax Notoginseng Saponins on Cardiovascular Diseases: A Comprehensive Overview of Experimental Studies
title_short Protective Effects of Panax Notoginseng Saponins on Cardiovascular Diseases: A Comprehensive Overview of Experimental Studies
title_sort protective effects of panax notoginseng saponins on cardiovascular diseases: a comprehensive overview of experimental studies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131460/
https://www.ncbi.nlm.nih.gov/pubmed/25152758
http://dx.doi.org/10.1155/2014/204840
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