Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception

Leukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation. Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth...

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Detalles Bibliográficos
Autores principales: Salleh, Naguib, Giribabu, Nelli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131495/
https://www.ncbi.nlm.nih.gov/pubmed/25152902
http://dx.doi.org/10.1155/2014/201514
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author Salleh, Naguib
Giribabu, Nelli
author_facet Salleh, Naguib
Giribabu, Nelli
author_sort Salleh, Naguib
collection PubMed
description Leukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation. Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth and development, embryo-endometrial interaction, trophoblast invasion, and immune modulation. Due to its critical role, LIF has been a target for a nonhormonal contraception. In this review, we summarize up-to-date information on the role of LIF in implantation and its role in contraception.
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spelling pubmed-41314952014-08-24 Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception Salleh, Naguib Giribabu, Nelli ScientificWorldJournal Review Article Leukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation. Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth and development, embryo-endometrial interaction, trophoblast invasion, and immune modulation. Due to its critical role, LIF has been a target for a nonhormonal contraception. In this review, we summarize up-to-date information on the role of LIF in implantation and its role in contraception. Hindawi Publishing Corporation 2014 2014-07-24 /pmc/articles/PMC4131495/ /pubmed/25152902 http://dx.doi.org/10.1155/2014/201514 Text en Copyright © 2014 N. Salleh and N. Giribabu. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Salleh, Naguib
Giribabu, Nelli
Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception
title Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception
title_full Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception
title_fullStr Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception
title_full_unstemmed Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception
title_short Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception
title_sort leukemia inhibitory factor: roles in embryo implantation and in nonhormonal contraception
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131495/
https://www.ncbi.nlm.nih.gov/pubmed/25152902
http://dx.doi.org/10.1155/2014/201514
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