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Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense

Four new limonoids, dysohainanins A–D (1–4), and two new triterpenoids, dysohainanins E and F (5 and 6), together with seven known ones were isolated from the twigs and leaves of Dysoxylum hainanense Merr. The structures of the new compounds were determined by a variety of spectroscopic methods. The...

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Autores principales: Liu, Wen-Xing, Tang, Gui-Hua, He, Hong-Ping, Zhang, Yu, Li, Shun-Lin, Hao, Xiao-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131571/
http://dx.doi.org/10.1007/s13659-011-0030-8
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author Liu, Wen-Xing
Tang, Gui-Hua
He, Hong-Ping
Zhang, Yu
Li, Shun-Lin
Hao, Xiao-Jiang
author_facet Liu, Wen-Xing
Tang, Gui-Hua
He, Hong-Ping
Zhang, Yu
Li, Shun-Lin
Hao, Xiao-Jiang
author_sort Liu, Wen-Xing
collection PubMed
description Four new limonoids, dysohainanins A–D (1–4), and two new triterpenoids, dysohainanins E and F (5 and 6), together with seven known ones were isolated from the twigs and leaves of Dysoxylum hainanense Merr. The structures of the new compounds were determined by a variety of spectroscopic methods. The cytotoxic activities of these compounds were evaluated, and the known compound ent-19-nor-4,16,18-trihydroxy-8(14)-pomaren-15-one (13) showed in vitro cytotoxicity against HL-60, A-549, MCF-7, and SW480 cells, with IC(50) values of 24.3, 28.1, 30.7, and 22.5 µM, respectively. Compounds 2 and 3 were tested their insecticidal activities using brine shrimp and both of them were inactive. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-011-0030-8 and is accessible for authorized users.
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spelling pubmed-41315712014-08-20 Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense Liu, Wen-Xing Tang, Gui-Hua He, Hong-Ping Zhang, Yu Li, Shun-Lin Hao, Xiao-Jiang Nat Prod Bioprospect Regular Article Four new limonoids, dysohainanins A–D (1–4), and two new triterpenoids, dysohainanins E and F (5 and 6), together with seven known ones were isolated from the twigs and leaves of Dysoxylum hainanense Merr. The structures of the new compounds were determined by a variety of spectroscopic methods. The cytotoxic activities of these compounds were evaluated, and the known compound ent-19-nor-4,16,18-trihydroxy-8(14)-pomaren-15-one (13) showed in vitro cytotoxicity against HL-60, A-549, MCF-7, and SW480 cells, with IC(50) values of 24.3, 28.1, 30.7, and 22.5 µM, respectively. Compounds 2 and 3 were tested their insecticidal activities using brine shrimp and both of them were inactive. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-011-0030-8 and is accessible for authorized users. Springer Berlin Heidelberg 2012-02-22 /pmc/articles/PMC4131571/ http://dx.doi.org/10.1007/s13659-011-0030-8 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by/4.0/ This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Regular Article
Liu, Wen-Xing
Tang, Gui-Hua
He, Hong-Ping
Zhang, Yu
Li, Shun-Lin
Hao, Xiao-Jiang
Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense
title Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense
title_full Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense
title_fullStr Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense
title_full_unstemmed Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense
title_short Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense
title_sort limonoids and triterpenoids from the twigs and leaves of dysoxylum hainanense
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131571/
http://dx.doi.org/10.1007/s13659-011-0030-8
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