Cargando…
Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich’in Native Americans
The Gwich’in, which belong to the Athapaskan language group of Native Americans live in the borderland between Alaska and Canada. We analyzed 29 medicinal plants of this tribe for their growth inhibitory activity against CCRF-CEM T-cell acute lymphoblastic leukemia (T-ALL) cells. The anti-leukemic a...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131572/ http://dx.doi.org/10.1007/s13659-012-0013-4 |
_version_ | 1782330482892996608 |
---|---|
author | Deeg, Katharina Eichhorn, Tolga Alexie, Gladys Kretschmer, Nadine Andersch, Kai Bauer, Rudolf Efferth, Thomas |
author_facet | Deeg, Katharina Eichhorn, Tolga Alexie, Gladys Kretschmer, Nadine Andersch, Kai Bauer, Rudolf Efferth, Thomas |
author_sort | Deeg, Katharina |
collection | PubMed |
description | The Gwich’in, which belong to the Athapaskan language group of Native Americans live in the borderland between Alaska and Canada. We analyzed 29 medicinal plants of this tribe for their growth inhibitory activity against CCRF-CEM T-cell acute lymphoblastic leukemia (T-ALL) cells. The anti-leukemic activity of these plants has not been investigated as yet. Considering the poor cure rates of some ALL forms, there might be a great potential for medicinal plants as resource for natural products to treat T-ALL. We found that the hexane extracts of three plants revealed considerable growth inhibition on CCRF-CEM cells. The 50% inhibition concentrations (IC(50)) were 6.63 ± 0.03 µg/ml for Cladina mitis, 8.65 ± 0.38 µg/ml for Picea mariana (needles), and 9.67 ± 1.36 µg/ml for Artemisia frigida. Further investigations are required to isolate the active constituents of these plants. [Image: see text] |
format | Online Article Text |
id | pubmed-4131572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-41315722014-08-20 Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich’in Native Americans Deeg, Katharina Eichhorn, Tolga Alexie, Gladys Kretschmer, Nadine Andersch, Kai Bauer, Rudolf Efferth, Thomas Nat Prod Bioprospect Regular Article The Gwich’in, which belong to the Athapaskan language group of Native Americans live in the borderland between Alaska and Canada. We analyzed 29 medicinal plants of this tribe for their growth inhibitory activity against CCRF-CEM T-cell acute lymphoblastic leukemia (T-ALL) cells. The anti-leukemic activity of these plants has not been investigated as yet. Considering the poor cure rates of some ALL forms, there might be a great potential for medicinal plants as resource for natural products to treat T-ALL. We found that the hexane extracts of three plants revealed considerable growth inhibition on CCRF-CEM cells. The 50% inhibition concentrations (IC(50)) were 6.63 ± 0.03 µg/ml for Cladina mitis, 8.65 ± 0.38 µg/ml for Picea mariana (needles), and 9.67 ± 1.36 µg/ml for Artemisia frigida. Further investigations are required to isolate the active constituents of these plants. [Image: see text] Springer Berlin Heidelberg 2012-02-24 /pmc/articles/PMC4131572/ http://dx.doi.org/10.1007/s13659-012-0013-4 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Regular Article Deeg, Katharina Eichhorn, Tolga Alexie, Gladys Kretschmer, Nadine Andersch, Kai Bauer, Rudolf Efferth, Thomas Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich’in Native Americans |
title | Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich’in Native Americans |
title_full | Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich’in Native Americans |
title_fullStr | Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich’in Native Americans |
title_full_unstemmed | Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich’in Native Americans |
title_short | Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich’in Native Americans |
title_sort | growth inhibition of human acute lymphoblastic ccrf-cem leukemia cells by medicinal plants of the west-canadian gwich’in native americans |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131572/ http://dx.doi.org/10.1007/s13659-012-0013-4 |
work_keys_str_mv | AT deegkatharina growthinhibitionofhumanacutelymphoblasticccrfcemleukemiacellsbymedicinalplantsofthewestcanadiangwichinnativeamericans AT eichhorntolga growthinhibitionofhumanacutelymphoblasticccrfcemleukemiacellsbymedicinalplantsofthewestcanadiangwichinnativeamericans AT alexiegladys growthinhibitionofhumanacutelymphoblasticccrfcemleukemiacellsbymedicinalplantsofthewestcanadiangwichinnativeamericans AT kretschmernadine growthinhibitionofhumanacutelymphoblasticccrfcemleukemiacellsbymedicinalplantsofthewestcanadiangwichinnativeamericans AT anderschkai growthinhibitionofhumanacutelymphoblasticccrfcemleukemiacellsbymedicinalplantsofthewestcanadiangwichinnativeamericans AT bauerrudolf growthinhibitionofhumanacutelymphoblasticccrfcemleukemiacellsbymedicinalplantsofthewestcanadiangwichinnativeamericans AT efferththomas growthinhibitionofhumanacutelymphoblasticccrfcemleukemiacellsbymedicinalplantsofthewestcanadiangwichinnativeamericans |