Cytosporinols A-C, new caryophyllene sesquiterpenoids from Cytospora sp.

Three new caryophyllene sesquiterpenoids, cytosporinols A-C (1–3), have been isolated from solid cultures of Cytospora sp. The structures of 1–3 were elucidated primarily by NMR spectroscopy, and 3 was further confirmed by X-ray crystallography. The absolute configurations of the C-11 secondary alco...

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Detalles Bibliográficos
Autores principales: Li, Yan, Li, Chang-Wei, Cui, Cheng-Bin, Liu, Xing-Zhong, Che, Yong-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2012
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131587/
http://dx.doi.org/10.1007/s13659-012-0018-z
Descripción
Sumario:Three new caryophyllene sesquiterpenoids, cytosporinols A-C (1–3), have been isolated from solid cultures of Cytospora sp. The structures of 1–3 were elucidated primarily by NMR spectroscopy, and 3 was further confirmed by X-ray crystallography. The absolute configurations of the C-11 secondary alcohol in 1 and the 6,8-diol moiety in 3 were deduced using the modified Mosher and Snatzke’s method, respectively. Compounds 2 and 3 showed moderate cytotoxicity against HeLa cells. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-012-0018-z and is accessible for authorized users.

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