Isochromophilones from an endophytic fungus Diaporthe sp.

Three new azaphilone compounds, isochromophilones X–XII (1–3), together with two known ones sclerotioramine (4) and isochromophilone VI (5) were isolated from the cultures of an endophytic fungus Diaporthe sp. The structures were elucidated by extensive HRESIMS and NMR spectroscopic analyses. All co...

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Autores principales: Zang, Le-Yun, Wei, Wei, Wang, Ting, Guo, Ye, Tan, Ren-Xiang, Ge, Hui-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2012
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131592/
http://dx.doi.org/10.1007/s13659-012-0023-2
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author Zang, Le-Yun
Wei, Wei
Wang, Ting
Guo, Ye
Tan, Ren-Xiang
Ge, Hui-Ming
author_facet Zang, Le-Yun
Wei, Wei
Wang, Ting
Guo, Ye
Tan, Ren-Xiang
Ge, Hui-Ming
author_sort Zang, Le-Yun
collection PubMed
description Three new azaphilone compounds, isochromophilones X–XII (1–3), together with two known ones sclerotioramine (4) and isochromophilone VI (5) were isolated from the cultures of an endophytic fungus Diaporthe sp. The structures were elucidated by extensive HRESIMS and NMR spectroscopic analyses. All compounds were tested for their cytotoxicities against five human cancer cell lines by MTT method, among which compound 1 showed moderate inhibitory effects on these cell lines. This was the first report of azaphilones isolated from Diaporthe sp. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-012-0023-2 and is accessible for authorized users.
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spelling pubmed-41315922014-08-20 Isochromophilones from an endophytic fungus Diaporthe sp. Zang, Le-Yun Wei, Wei Wang, Ting Guo, Ye Tan, Ren-Xiang Ge, Hui-Ming Nat Prod Bioprospect Regular Article Three new azaphilone compounds, isochromophilones X–XII (1–3), together with two known ones sclerotioramine (4) and isochromophilone VI (5) were isolated from the cultures of an endophytic fungus Diaporthe sp. The structures were elucidated by extensive HRESIMS and NMR spectroscopic analyses. All compounds were tested for their cytotoxicities against five human cancer cell lines by MTT method, among which compound 1 showed moderate inhibitory effects on these cell lines. This was the first report of azaphilones isolated from Diaporthe sp. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-012-0023-2 and is accessible for authorized users. Springer Berlin Heidelberg 2012-04-13 /pmc/articles/PMC4131592/ http://dx.doi.org/10.1007/s13659-012-0023-2 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Regular Article
Zang, Le-Yun
Wei, Wei
Wang, Ting
Guo, Ye
Tan, Ren-Xiang
Ge, Hui-Ming
Isochromophilones from an endophytic fungus Diaporthe sp.
title Isochromophilones from an endophytic fungus Diaporthe sp.
title_full Isochromophilones from an endophytic fungus Diaporthe sp.
title_fullStr Isochromophilones from an endophytic fungus Diaporthe sp.
title_full_unstemmed Isochromophilones from an endophytic fungus Diaporthe sp.
title_short Isochromophilones from an endophytic fungus Diaporthe sp.
title_sort isochromophilones from an endophytic fungus diaporthe sp.
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131592/
http://dx.doi.org/10.1007/s13659-012-0023-2
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