Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity

Three new sesquilignans, 1–3, a new sesquiterpenoid, 4, and three known compounds were isolated from the stem barks of Illicium simonsii. The structures of new compounds (1–4) were elucidated by spectroscopic methods. A biosynthetic pathway was proposed for simonsienols A-C (1–3). Anti-AChE activity...

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Detalles Bibliográficos
Autores principales: Dong, Chuan-Fu, Liu, Lei, Luo, Huai-Rong, Li, Xiao-Nian, Guan, Zheng-Ye, Wang, Yi-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2012
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131593/
http://dx.doi.org/10.1007/s13659-012-0026-z
Descripción
Sumario:Three new sesquilignans, 1–3, a new sesquiterpenoid, 4, and three known compounds were isolated from the stem barks of Illicium simonsii. The structures of new compounds (1–4) were elucidated by spectroscopic methods. A biosynthetic pathway was proposed for simonsienols A-C (1–3). Anti-AChE activity and anti-BuChE activity were evaluated for all compounds except for α-cadinol ethyl ether (4). As a result, isodunnianol (7) exhibited anti-AChE activity with an IC(50) value of 13.0 µM. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-012-0026-z and is accessible for authorized users.

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