Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity

Three new sesquilignans, 1–3, a new sesquiterpenoid, 4, and three known compounds were isolated from the stem barks of Illicium simonsii. The structures of new compounds (1–4) were elucidated by spectroscopic methods. A biosynthetic pathway was proposed for simonsienols A-C (1–3). Anti-AChE activity...

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Detalles Bibliográficos
Autores principales: Dong, Chuan-Fu, Liu, Lei, Luo, Huai-Rong, Li, Xiao-Nian, Guan, Zheng-Ye, Wang, Yi-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2012
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131593/
http://dx.doi.org/10.1007/s13659-012-0026-z
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author Dong, Chuan-Fu
Liu, Lei
Luo, Huai-Rong
Li, Xiao-Nian
Guan, Zheng-Ye
Wang, Yi-Fen
author_facet Dong, Chuan-Fu
Liu, Lei
Luo, Huai-Rong
Li, Xiao-Nian
Guan, Zheng-Ye
Wang, Yi-Fen
author_sort Dong, Chuan-Fu
collection PubMed
description Three new sesquilignans, 1–3, a new sesquiterpenoid, 4, and three known compounds were isolated from the stem barks of Illicium simonsii. The structures of new compounds (1–4) were elucidated by spectroscopic methods. A biosynthetic pathway was proposed for simonsienols A-C (1–3). Anti-AChE activity and anti-BuChE activity were evaluated for all compounds except for α-cadinol ethyl ether (4). As a result, isodunnianol (7) exhibited anti-AChE activity with an IC(50) value of 13.0 µM. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-012-0026-z and is accessible for authorized users.
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spelling pubmed-41315932014-08-20 Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity Dong, Chuan-Fu Liu, Lei Luo, Huai-Rong Li, Xiao-Nian Guan, Zheng-Ye Wang, Yi-Fen Nat Prod Bioprospect Regular Article Three new sesquilignans, 1–3, a new sesquiterpenoid, 4, and three known compounds were isolated from the stem barks of Illicium simonsii. The structures of new compounds (1–4) were elucidated by spectroscopic methods. A biosynthetic pathway was proposed for simonsienols A-C (1–3). Anti-AChE activity and anti-BuChE activity were evaluated for all compounds except for α-cadinol ethyl ether (4). As a result, isodunnianol (7) exhibited anti-AChE activity with an IC(50) value of 13.0 µM. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-012-0026-z and is accessible for authorized users. Springer Berlin Heidelberg 2012-05-24 /pmc/articles/PMC4131593/ http://dx.doi.org/10.1007/s13659-012-0026-z Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Regular Article
Dong, Chuan-Fu
Liu, Lei
Luo, Huai-Rong
Li, Xiao-Nian
Guan, Zheng-Ye
Wang, Yi-Fen
Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity
title Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity
title_full Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity
title_fullStr Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity
title_full_unstemmed Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity
title_short Sesquilignans and sesquiterpenoid from the stem barks of Illicium simonsii and their anti-AChE activity
title_sort sesquilignans and sesquiterpenoid from the stem barks of illicium simonsii and their anti-ache activity
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131593/
http://dx.doi.org/10.1007/s13659-012-0026-z
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