Cipatrijugin G, a new trijugin-type limonoid bearing an uncommon γ-hydroxybutenolide unit from the aerial parts of Cipadessa cinerascens

A new trijugin-type limonoid, cipatrijugin G (1), together with the related known cipatrijugin A (2), were isolated from the aerial parts of Cipadessa cinerascens. The structure of the new compound was determined by extensive analysis of its spectroscopic data and by comparison of its NMR data with those reported in the literature. Compound 1 showed cytotoxicity against tumor cell line A549 with an IC(50) value of 9.78 μM. This is the first report of a trijugin-type limonoid bearing a γ-hydroxybutenolide unit, in comparison to the common furan unit as ring E. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-013-0074-z and is accessible for authorized users.