Hypercohones A–C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens

Three new homo-adamantanyl type natural products were derived from polyprenylated polycyclic acylphloroglucinol. Hypercohones A-C (1–3), along with five other known hypercohones (4–8), were isolated from the aerial parts of Hypericum cohaerens. The structures of 1–3 were elucidated on the basis of c...

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Autores principales: Liu, Xia, Yang, Xing-Wei, Chen, Chao-Qun, Wu, Chun-Yan, Zhang, Jing-Jing, Ma, Jun-Zeng, Wang, Huan, Zhao, Qin-Shi, Yang, Li-Xin, Xu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131619/
http://dx.doi.org/10.1007/s13659-013-0032-9
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author Liu, Xia
Yang, Xing-Wei
Chen, Chao-Qun
Wu, Chun-Yan
Zhang, Jing-Jing
Ma, Jun-Zeng
Wang, Huan
Zhao, Qin-Shi
Yang, Li-Xin
Xu, Gang
author_facet Liu, Xia
Yang, Xing-Wei
Chen, Chao-Qun
Wu, Chun-Yan
Zhang, Jing-Jing
Ma, Jun-Zeng
Wang, Huan
Zhao, Qin-Shi
Yang, Li-Xin
Xu, Gang
author_sort Liu, Xia
collection PubMed
description Three new homo-adamantanyl type natural products were derived from polyprenylated polycyclic acylphloroglucinol. Hypercohones A-C (1–3), along with five other known hypercohones (4–8), were isolated from the aerial parts of Hypericum cohaerens. The structures of 1–3 were elucidated on the basis of comprehensive spectroscopic analysis. The inhibitory activities of these isolates against five human cancer cell lines in vitro were tested. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-013-0032-9 and is accessible for authorized users.
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spelling pubmed-41316192014-08-20 Hypercohones A–C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens Liu, Xia Yang, Xing-Wei Chen, Chao-Qun Wu, Chun-Yan Zhang, Jing-Jing Ma, Jun-Zeng Wang, Huan Zhao, Qin-Shi Yang, Li-Xin Xu, Gang Nat Prod Bioprospect Regular Article Three new homo-adamantanyl type natural products were derived from polyprenylated polycyclic acylphloroglucinol. Hypercohones A-C (1–3), along with five other known hypercohones (4–8), were isolated from the aerial parts of Hypericum cohaerens. The structures of 1–3 were elucidated on the basis of comprehensive spectroscopic analysis. The inhibitory activities of these isolates against five human cancer cell lines in vitro were tested. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-013-0032-9 and is accessible for authorized users. Springer Berlin Heidelberg 2013-09-06 /pmc/articles/PMC4131619/ http://dx.doi.org/10.1007/s13659-013-0032-9 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/4.0/ This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Regular Article
Liu, Xia
Yang, Xing-Wei
Chen, Chao-Qun
Wu, Chun-Yan
Zhang, Jing-Jing
Ma, Jun-Zeng
Wang, Huan
Zhao, Qin-Shi
Yang, Li-Xin
Xu, Gang
Hypercohones A–C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens
title Hypercohones A–C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens
title_full Hypercohones A–C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens
title_fullStr Hypercohones A–C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens
title_full_unstemmed Hypercohones A–C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens
title_short Hypercohones A–C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens
title_sort hypercohones a–c, acylphloroglucinol derivatives with homo-adamantane cores from hypericum cohaerens
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131619/
http://dx.doi.org/10.1007/s13659-013-0032-9
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