Five new mexicanolide type limonoids from Heynea trijuga

Five new mexicanolide-type limonoids, heytrijunolides A–E (1–5) were isolated from the branches and leaves of Heynea trijuga. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analysis. Compound 3 showed weak cytotoxicity against HL-60, SMMC-7721 and A-549...

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Detalles Bibliográficos
Autores principales: Yang, Wei, Kong, Ling-Mei, Li, Shi-Fei, Li, Yan, Zhang, Yu, He, Hong-Ping, Hao, Xiao-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2012
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131624/
http://dx.doi.org/10.1007/s13659-012-0040-1
Descripción
Sumario:Five new mexicanolide-type limonoids, heytrijunolides A–E (1–5) were isolated from the branches and leaves of Heynea trijuga. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analysis. Compound 3 showed weak cytotoxicity against HL-60, SMMC-7721 and A-549 human tumor cell lines with the IC(50) values of 21.88, 20.66 and 12.70 µM, respectively. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-012-0040-1 and is accessible for authorized users.

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