Betanidin significantly reduces blood glucose levels in BALB/c mice fed with an atherogenic diet

Six weeks BALB/c mice were fed with an atherogenic diet for 24 weeks and purified water ad libitum. An experimental group was given betanidin, orally, during the last 40 days of the experiment at a dose of 9.6 mg per mouse per day. Negative controls were fed with standard rodent chow only. Glycemia was measured at the end of the experiment, after overnight fasting. The group treated with betanidin presented a highly significant reduction of 50.94% compared to positive controls. We conclude that betanidin reduces glycemia in BALB/c mice by an unidentified mechanism. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-012-0034-z and is accessible for authorized users.