Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii

Three new ent-kauranoids, isorosthornins A-C (1–3), and a new natural product, dihydroponicidin (4), together with five known ones were isolated from the aerial parts of Isodon rosthornii. The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were eva...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhan, Rui, Du, Xue, Su, Jia, Li, Xiao-Nian, Wang, Wei-Guang, Liang, Cheng-Qin, Yang, Jian-Hong, Li, Yan, Pu, Jian-Xin, Sun, Han-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2011
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131646/
http://dx.doi.org/10.1007/s13659-011-0031-7
Descripción
Sumario:Three new ent-kauranoids, isorosthornins A-C (1–3), and a new natural product, dihydroponicidin (4), together with five known ones were isolated from the aerial parts of Isodon rosthornii. The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines, and compounds 5 and 7 showed significant inhibitory effects on all cell lines. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-011-0031-7 and is accessible for authorized users.

Ejemplares similares