Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii

Three new ent-kauranoids, isorosthornins A-C (1–3), and a new natural product, dihydroponicidin (4), together with five known ones were isolated from the aerial parts of Isodon rosthornii. The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were eva...

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Autores principales: Zhan, Rui, Du, Xue, Su, Jia, Li, Xiao-Nian, Wang, Wei-Guang, Liang, Cheng-Qin, Yang, Jian-Hong, Li, Yan, Pu, Jian-Xin, Sun, Han-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2011
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131646/
http://dx.doi.org/10.1007/s13659-011-0031-7
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author Zhan, Rui
Du, Xue
Su, Jia
Li, Xiao-Nian
Wang, Wei-Guang
Liang, Cheng-Qin
Yang, Jian-Hong
Li, Yan
Pu, Jian-Xin
Sun, Han-Dong
author_facet Zhan, Rui
Du, Xue
Su, Jia
Li, Xiao-Nian
Wang, Wei-Guang
Liang, Cheng-Qin
Yang, Jian-Hong
Li, Yan
Pu, Jian-Xin
Sun, Han-Dong
author_sort Zhan, Rui
collection PubMed
description Three new ent-kauranoids, isorosthornins A-C (1–3), and a new natural product, dihydroponicidin (4), together with five known ones were isolated from the aerial parts of Isodon rosthornii. The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines, and compounds 5 and 7 showed significant inhibitory effects on all cell lines. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-011-0031-7 and is accessible for authorized users.
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spelling pubmed-41316462014-08-20 Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii Zhan, Rui Du, Xue Su, Jia Li, Xiao-Nian Wang, Wei-Guang Liang, Cheng-Qin Yang, Jian-Hong Li, Yan Pu, Jian-Xin Sun, Han-Dong Nat Prod Bioprospect Regular Article Three new ent-kauranoids, isorosthornins A-C (1–3), and a new natural product, dihydroponicidin (4), together with five known ones were isolated from the aerial parts of Isodon rosthornii. The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines, and compounds 5 and 7 showed significant inhibitory effects on all cell lines. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-011-0031-7 and is accessible for authorized users. Springer Berlin Heidelberg 2011-12-12 /pmc/articles/PMC4131646/ http://dx.doi.org/10.1007/s13659-011-0031-7 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by/4.0/ This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Regular Article
Zhan, Rui
Du, Xue
Su, Jia
Li, Xiao-Nian
Wang, Wei-Guang
Liang, Cheng-Qin
Yang, Jian-Hong
Li, Yan
Pu, Jian-Xin
Sun, Han-Dong
Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii
title Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii
title_full Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii
title_fullStr Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii
title_full_unstemmed Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii
title_short Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii
title_sort isorosthornins a-c, new ent-kaurane diterpenoids from isodon rosthornii
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131646/
http://dx.doi.org/10.1007/s13659-011-0031-7
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