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neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies
Salvia dugesii is an invasive plant in Yunnan, China. To tentatively explore its utilization, a systematic phytochemical investigation was carried out on this plant, which led to the isolation of five new neo-clerodane diterpenoids, dugesins C–G (1–5), together with six known ones. Their structures...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131648/ http://dx.doi.org/10.1007/s13659-011-0016-6 |
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author | Gang, Xu Fang, Zhao Xian-Wen, Yang Juan, Zhou Li-Xin, Yang Shen, Xiao-Ling Hu, Ying-Jie Zhao, Qin-Shi |
author_facet | Gang, Xu Fang, Zhao Xian-Wen, Yang Juan, Zhou Li-Xin, Yang Shen, Xiao-Ling Hu, Ying-Jie Zhao, Qin-Shi |
author_sort | Gang, Xu |
collection | PubMed |
description | Salvia dugesii is an invasive plant in Yunnan, China. To tentatively explore its utilization, a systematic phytochemical investigation was carried out on this plant, which led to the isolation of five new neo-clerodane diterpenoids, dugesins C–G (1–5), together with six known ones. Their structures were determined by comprehensive NMR and MS spectroscopic analysis. It was noteworthy that the eleven isolates, composed of five different carbocyclic systems derived from the neo-clerodane diterpenoid skeleton, were reported from the same plant for the first time. The anti-feedantial, cytotoxic, and antiviral activities of the isolates were evaluated. Dugesin F (4) was tested to be a non-toxic antiviral compound against influenza virus FM1. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-011-0016-6 and is accessible for authorized users. |
format | Online Article Text |
id | pubmed-4131648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-41316482014-08-20 neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies Gang, Xu Fang, Zhao Xian-Wen, Yang Juan, Zhou Li-Xin, Yang Shen, Xiao-Ling Hu, Ying-Jie Zhao, Qin-Shi Nat Prod Bioprospect Regular Article Salvia dugesii is an invasive plant in Yunnan, China. To tentatively explore its utilization, a systematic phytochemical investigation was carried out on this plant, which led to the isolation of five new neo-clerodane diterpenoids, dugesins C–G (1–5), together with six known ones. Their structures were determined by comprehensive NMR and MS spectroscopic analysis. It was noteworthy that the eleven isolates, composed of five different carbocyclic systems derived from the neo-clerodane diterpenoid skeleton, were reported from the same plant for the first time. The anti-feedantial, cytotoxic, and antiviral activities of the isolates were evaluated. Dugesin F (4) was tested to be a non-toxic antiviral compound against influenza virus FM1. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-011-0016-6 and is accessible for authorized users. Springer Berlin Heidelberg 2011-10-14 /pmc/articles/PMC4131648/ http://dx.doi.org/10.1007/s13659-011-0016-6 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by/4.0/ This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Regular Article Gang, Xu Fang, Zhao Xian-Wen, Yang Juan, Zhou Li-Xin, Yang Shen, Xiao-Ling Hu, Ying-Jie Zhao, Qin-Shi neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies |
title | neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies |
title_full | neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies |
title_fullStr | neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies |
title_full_unstemmed | neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies |
title_short | neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies |
title_sort | neo-clerodane diterpenoids from salvia dugesii and their bioactive studies |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131648/ http://dx.doi.org/10.1007/s13659-011-0016-6 |
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