Chemical investigation on the cultures of the fungus Xylaria carpophila

A chemical investigation on the cultures of Xylaria carpophila led to the isolation of one known cyclopeptide cyclo(Nmethyl-(l)-Phe-(l)-Pro-(l)-Leu-(d)-Ile-(l)-Val) (1), five new sesquiterpenes, named as xylcarpins A–E (2–6), and another known compound (7). The structures were determined by extensiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Yin, Xia, Feng, Tao, Li, Zheng-Hui, Su, Jia, Li, Yan, Tan, Ning-Hua, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2011
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131652/
http://dx.doi.org/10.1007/s13659-011-0011-y
Descripción
Sumario:A chemical investigation on the cultures of Xylaria carpophila led to the isolation of one known cyclopeptide cyclo(Nmethyl-(l)-Phe-(l)-Pro-(l)-Leu-(d)-Ile-(l)-Val) (1), five new sesquiterpenes, named as xylcarpins A–E (2–6), and another known compound (7). The structures were determined by extensive NMR and MS spectroscopic analysis. The absolute configuration of 1 was established by use of Marfey’s method and ROESY spectroscopic data. All compounds were tested for their cytotoxicities against five human cancer cell lines. Compound 7 showed week inhibitory activity. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-011-0011-y and is accessible for authorized users.

Ejemplares similares