Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities

15 compounds, including two new ones crepidatuols A (1) and B (2) were isolated from the stems of Dendrobium crepidatum. The planar structures of these compounds were elucidated by spectroscopic methods (NMR, MS, UV, and IR) and comparison with those from literatures. 10 compounds were send for enha...

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Detalles Bibliográficos
Autores principales: Li, Cheng-Bo, Wang, Cong, Fan, Wei-Wei, Dong, Fa-Wu, Xu, Feng-Qing, Wan, Qin-Li, Luo, Huai-Rong, Liu, Yu-Qing, Hu, Jiang-Miao, Zhou, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131658/
http://dx.doi.org/10.1007/s13659-012-0103-3
Descripción
Sumario:15 compounds, including two new ones crepidatuols A (1) and B (2) were isolated from the stems of Dendrobium crepidatum. The planar structures of these compounds were elucidated by spectroscopic methods (NMR, MS, UV, and IR) and comparison with those from literatures. 10 compounds were send for enhancing activities on nerve growth factor (NGF) medicated neurite outgrowth in PC12 cells and the results indicated that crepidatuol A (1), confusarin and 3-(2-acetoxy-5-methoxy)-phenylpropanol showed enhancing activities at the concentration of 10.0 µM. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-012-0103-3 and is accessible for authorized users.

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