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Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner

Dendrowardol C (1)—a novel sesquiterpenoid, with an unprecedented 4/5/6/6 tetracyclic carbon backbone, together with two known cyclopacamphane-type sesquiterpenoids; dendronobilin I (2) and dendrobane A (3) were isolated from the stems of Dendrobium wardianum Warner. The structure of 1 was establish...

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Detalles Bibliográficos
Autores principales: Fan, Wei-Wei, Xu, Feng-Qing, Dong, Fa-Wu, Li, Xiao-Nian, Li, Yan, Liu, Yu-Qing, Zhou, Jun, Hu, Jiang-Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131667/
http://dx.doi.org/10.1007/s13659-013-0024-9
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author Fan, Wei-Wei
Xu, Feng-Qing
Dong, Fa-Wu
Li, Xiao-Nian
Li, Yan
Liu, Yu-Qing
Zhou, Jun
Hu, Jiang-Miao
author_facet Fan, Wei-Wei
Xu, Feng-Qing
Dong, Fa-Wu
Li, Xiao-Nian
Li, Yan
Liu, Yu-Qing
Zhou, Jun
Hu, Jiang-Miao
author_sort Fan, Wei-Wei
collection PubMed
description Dendrowardol C (1)—a novel sesquiterpenoid, with an unprecedented 4/5/6/6 tetracyclic carbon backbone, together with two known cyclopacamphane-type sesquiterpenoids; dendronobilin I (2) and dendrobane A (3) were isolated from the stems of Dendrobium wardianum Warner. The structure of 1 was established on the basis of spectroscopic data and the absolute configuration was determined by single-crystal X-ray diffraction crystallography. The hypothetical biosynthetic pathway of 1 was postulated. Compound 1 showed no cytotoxic activity against human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-013-0024-9 and is accessible for authorized users.
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spelling pubmed-41316672014-08-20 Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner Fan, Wei-Wei Xu, Feng-Qing Dong, Fa-Wu Li, Xiao-Nian Li, Yan Liu, Yu-Qing Zhou, Jun Hu, Jiang-Miao Nat Prod Bioprospect Regular Article Dendrowardol C (1)—a novel sesquiterpenoid, with an unprecedented 4/5/6/6 tetracyclic carbon backbone, together with two known cyclopacamphane-type sesquiterpenoids; dendronobilin I (2) and dendrobane A (3) were isolated from the stems of Dendrobium wardianum Warner. The structure of 1 was established on the basis of spectroscopic data and the absolute configuration was determined by single-crystal X-ray diffraction crystallography. The hypothetical biosynthetic pathway of 1 was postulated. Compound 1 showed no cytotoxic activity against human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-013-0024-9 and is accessible for authorized users. Springer Berlin Heidelberg 2013-04-24 /pmc/articles/PMC4131667/ http://dx.doi.org/10.1007/s13659-013-0024-9 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/4.0/ This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Regular Article
Fan, Wei-Wei
Xu, Feng-Qing
Dong, Fa-Wu
Li, Xiao-Nian
Li, Yan
Liu, Yu-Qing
Zhou, Jun
Hu, Jiang-Miao
Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner
title Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner
title_full Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner
title_fullStr Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner
title_full_unstemmed Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner
title_short Dendrowardol C, a novel sesquiterpenoid from Dendrobium wardianum Warner
title_sort dendrowardol c, a novel sesquiterpenoid from dendrobium wardianum warner
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131667/
http://dx.doi.org/10.1007/s13659-013-0024-9
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