Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis

Three new secoiridoids, swertiakoulactone (1) and swertiakosides A and B (2 and 3), were isolated from Swertia kouitchensis. Their structures were elucidated by comprehensive spectroscopic analyses including MS, IR, 1D and 2D NMR data. By the anti-hepatitis B virus (HBV) assay on Hep G 2.2.15 cells...

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Detalles Bibliográficos
Autores principales: He, Kang, Ma, Yun-Bao, Geng, Chang-An, Zhang, Xue-Mei, Cao, Tuan-Wu, Jiang, Fu-Qiang, Chen, Ji-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2011
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131710/
http://dx.doi.org/10.1007/s13659-011-0009-5
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author He, Kang
Ma, Yun-Bao
Geng, Chang-An
Zhang, Xue-Mei
Cao, Tuan-Wu
Jiang, Fu-Qiang
Chen, Ji-Jun
author_facet He, Kang
Ma, Yun-Bao
Geng, Chang-An
Zhang, Xue-Mei
Cao, Tuan-Wu
Jiang, Fu-Qiang
Chen, Ji-Jun
author_sort He, Kang
collection PubMed
description Three new secoiridoids, swertiakoulactone (1) and swertiakosides A and B (2 and 3), were isolated from Swertia kouitchensis. Their structures were elucidated by comprehensive spectroscopic analyses including MS, IR, 1D and 2D NMR data. By the anti-hepatitis B virus (HBV) assay on Hep G 2.2.15 cells line in vitro, compound 1 showed moderate activities inhibiting the HBsAg secretion (IC(50) = 1.10 mM, SI = 4.39) and HBV DNA replication (IC(50) = 1.16 mM, SI = 4.12). [Image: see text]
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spelling pubmed-41317102014-08-20 Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis He, Kang Ma, Yun-Bao Geng, Chang-An Zhang, Xue-Mei Cao, Tuan-Wu Jiang, Fu-Qiang Chen, Ji-Jun Nat Prod Bioprospect Regular Article Three new secoiridoids, swertiakoulactone (1) and swertiakosides A and B (2 and 3), were isolated from Swertia kouitchensis. Their structures were elucidated by comprehensive spectroscopic analyses including MS, IR, 1D and 2D NMR data. By the anti-hepatitis B virus (HBV) assay on Hep G 2.2.15 cells line in vitro, compound 1 showed moderate activities inhibiting the HBsAg secretion (IC(50) = 1.10 mM, SI = 4.39) and HBV DNA replication (IC(50) = 1.16 mM, SI = 4.12). [Image: see text] Springer Berlin Heidelberg 2011-09-05 /pmc/articles/PMC4131710/ http://dx.doi.org/10.1007/s13659-011-0009-5 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by/4.0/ This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Regular Article
He, Kang
Ma, Yun-Bao
Geng, Chang-An
Zhang, Xue-Mei
Cao, Tuan-Wu
Jiang, Fu-Qiang
Chen, Ji-Jun
Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis
title Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis
title_full Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis
title_fullStr Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis
title_full_unstemmed Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis
title_short Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis
title_sort anti-hepatitis b virus active secoiridoids from swertia kouitchensis
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131710/
http://dx.doi.org/10.1007/s13659-011-0009-5
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